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Updated: Jul 2, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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La degradación proteica dirigida a través de pegamentos bivalentes intramoleculares

Oliver Hsia1, Matthias Hinterndorfer2, Angus D Cowan1

  • 1Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK.

Nature
|February 21, 2024
PubMed
Resumen

Los adhesivos bivalentes intramoleculares (IBG) representan una nueva estrategia de degradación de proteínas dirigida. Estos compuestos inducen la degradación mediante la participación de los dominios de proteína objetivo en cis, mejorando la unión de la E3 ligasa y promoviendo la ubiquitinación.

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