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Updated: Jul 2, 2025

Genome Editing in Astyanax mexicanus Using Transcription Activator-like Effector Nucleases TALENs
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Sobre la base genética de la evolución de la pérdida de la cola en humanos y simios

Bo Xia1,2,3,4, Weimin Zhang5, Guisheng Zhao6,5

  • 1Institute for Computational Medicine, NYU Langone Health, New York, NY, USA. xiabo@broadinstitute.org.

Nature
|February 28, 2024
PubMed
Resumen

La pérdida de cola humana evolucionó a través de una inserción de elemento Alu en el gen TBXT, causando un empalme alternativo. Este cambio genético dio lugar a la ausencia de cola en los ratones, pero también condujo a defectos del tubo neural, lo que pone de relieve una compensación evolutiva.

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