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Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
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Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
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La movilidad auto-mejorada permite la formación de patrones de vórtice en la materia viva

Haoran Xu1, Yilin Wu2

  • 1Department of Physics and Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, P.R. China.

Nature
|March 14, 2024
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La densa materia viva bacteriana forma a gran escala, patrones ordenados de vórtices giratorios. Esta autoorganización es impulsada por las interacciones físicas y la movilidad celular mejorada, revelando un nuevo mecanismo para la formación de patrones en la materia activa.

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Área de la Ciencia:

  • Física de la materia activa
  • La autoorganización biológica
  • Microbiología

Sus antecedentes:

  • Los sistemas vivos exhiben estructuras auto-organizadas desde los niveles subcelulares hasta los organismos.
  • La formación de patrones biológicos a menudo se basa en la señalización química, pero las interacciones físicas también pueden impulsar el orden.

Objetivo del estudio:

  • Descubrir un nuevo mecanismo físico para la formación de patrones auto-organizados en sistemas bacterianos densos.
  • Investigar el surgimiento de estructuras espaciales a gran escala impulsadas por interacciones físicas.

Principales métodos:

  • Observación de las suspensiones bacterianas densas.
  • Análisis de seguimiento de una sola célula.
  • Simulaciones numéricas.

Principales resultados:

  • La densa materia viva bacteriana formó espontáneamente una red a escala de centímetros de vórtices de mezoscala y de rápido giro.
  • Cada vórtice contenía 10^4-10^5 células bacterianas móviles con orden hexagonal.
  • La movilidad celular auto-mejorada, impulsada por las tensiones colectivas, permitió esta formación de patrones.

Conclusiones:

  • La movilidad auto-mejorada proporciona un mecanismo físico simple para la formación de patrones en los sistemas vivos.
  • Este hallazgo es relevante para los sistemas de materia activa cerca de la transición fluido-sólido.