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Una ventana crítica dependiente de la quimiosensibilidad nasal para el desarrollo somatosensorial
Linbi Cai1,2, Ali Özgür Argunşah1,2, Angeliki Damilou1,2
1Laboratory of Neural Circuit Assembly, Brain Research Institute (HiFo), University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Science (New York, N.Y.)
|May 9, 2024
Resumen
El olfato en los primeros años de vida (quimiosensibilidad nasal) es vital para el desarrollo del cerebro. Este estudio muestra una ventana crítica donde el olfato da forma al desarrollo de la sensación de bigote en ratones.
Área de la Ciencia:
- La neurociencia
- Biología del desarrollo
- Sistemas sensoriales
Sus antecedentes:
- La quimiosensibilidad nasal es un sentido evolutivo antiguo, crítico para el bienestar neonatal junto con la somatosensibilidad.
- Las vías auditivas y visuales maduran más tarde, lo que sugiere que las modalidades sensoriales tempranas juegan un papel fundamental.
Objetivo del estudio:
- Investigar la influencia de la quimiosensibilidad nasal temprana en el desarrollo de la corteza somatosensorial primaria del bigote (wS1).
- Identificar la línea de tiempo de desarrollo y las interacciones transversales entre las vías olfativas y somatosensoriales.
Principales métodos:
- Utilizó enfoques anatómicos y funcionales en ratones.
- Se empleó la privación del olor neonatal seguida de análisis electrofisiológicos y conductuales en animales adultos.
Principales resultados:
- La actividad impulsada por el olor durante la primera semana postnatal aumenta la activación evocada por el bigote en wS1.
- Este efecto transversal disminuye en los adultos debido a la reducción de la conectividad de la corteza olfativa con wS1.
- La privación del olor en los neonatos perjudica la dinámica y la somatosensibilidad de la wS1 en adultos.
Conclusiones:
- Existe una ventana de desarrollo crítica donde la quimiosensibilidad nasal es necesaria para la maduración de la función somatosensorial.
- Esto pone de relieve una interacción intermodal crucial esencial para el desarrollo del sistema sensorial.
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