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El gen para el receptor de insulina humana: localización en el sitio del cromosoma 19 involucrado en la leucemia
Science (New York, N.Y.)
|May 10, 1985
Resumen
Las translocaciones cromosómicas pueden afectar la expresión proto-oncogénica. Los investigadores mapearon el gen receptor de insulina humana en el cromosoma 19, un sitio relacionado con el desarrollo de la leucemia.
Área de la Ciencia:
- Genética La genética.
- Biología Molecular Biología Molecular
- Oncología Oncología.
Sus antecedentes:
- Las translocaciones cromosómicas en el cáncer pueden alterar la expresión proto-oncogénica.
- El receptor de insulina humana comparte similitudes de secuencia con oncogenes como el receptor EGF (erbB) y los miembros de la familia src.
Objetivo del estudio:
- Para mapear la ubicación del gen receptor de insulina humana.
- Para investigar el papel potencial del gen en las translocaciones neoplásicas.
Principales métodos:
- La hibridación in situ se utilizó para determinar la ubicación del gen.
- El análisis de Southern blot de ADN híbrido de células somáticas confirmó el mapeo genético.
Principales resultados:
- El gen del receptor de insulina humana fue mapeado con éxito en el cromosoma 19, específicamente las bandas p13.2-p13.3.3.
- Se sabe que esta región cromosómica está involucrada en las translocaciones no aleatorias observadas en la leucemia aguda pre-B.
Conclusiones:
- La ubicación del gen receptor de insulina humana en el cromosoma 19 lo coloca en un sitio crítico para las translocaciones en ciertas leucemias.
- Este hallazgo sugiere un papel potencial para el gen receptor de insulina en la patogénesis de la leucemia aguda pre-B.
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