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El tiempo circadiano de la quimioterapia contra el cáncer
Science (New York, N.Y.)
|April 5, 1985
Resumen
La administración de los fármacos anticancerígenos adriamicina y cisplatino por la mañana redujo la toxicidad y las complicaciones del tratamiento. La administración de adriamicina por la noche seguida de cisplatino por la mañana aumentó los eventos adversos en pacientes con cáncer de ovario.
Área de la Ciencia:
- Oncología Oncología.
- Cronofarmacología cronofarmacología.
- Cáncer Quimioterapia Quimioterapia para el cáncer.
Sus antecedentes:
- Los estudios en animales sugieren que el tiempo circadiano afecta la toxicidad de los medicamentos anticancerígenos.
- La adriamicina y el cisplatino son agentes de quimioterapia comunes con toxicidades conocidas.
Objetivo del estudio:
- Investigar el impacto del tiempo de administración en la toxicidad de la adriamicina y el cisplatino en pacientes con cáncer de ovario.
- Para determinar si el ritmo circadiano influye en los efectos secundarios de la quimioterapia.
Principales métodos:
- 31 pacientes con cáncer de ovario avanzado recibieron ciclos mensuales de adriamicina seguidos 12 horas más tarde por cisplatino.
- La adriamicina se administró al azar a las 6 de la mañana o a las 6 de la tarde.
Principales resultados:
- El grupo de adriamicina por la noche/cisplatino por la mañana tenía el doble de pacientes que necesitaban reducción de dosis o retraso en el tratamiento.
- Este grupo también experimentó cuatro veces más retrasos en el tratamiento y tres veces más modificaciones en la dosis.
- A pesar de la atenuación de la dosis, las complicaciones del tratamiento se duplicaron en el grupo de adriamicina por la noche.
Conclusiones:
- El tiempo circadiano de administración de adriamicina y cisplatino impacta significativamente la toxicidad del paciente y los resultados del tratamiento.
- La optimización de los horarios de administración de quimioterapia basados en los ritmos circadianos puede mejorar la tolerabilidad y la eficacia.
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