Video Experimental Relacionado
Updated: Jun 24, 2025
07:49
Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
Published on: June 2, 2022
3.2K
La revelación de un mensajero: los microbios intestinales emiten una señal neuroactiva
Poulami Chatterjee1, Laura M K Dassama2
1Department of Chemistry, Stanford University, Stanford, CA, USA; Sarafan ChEM-H Institute, Stanford University, Stanford, CA, USA.
Cell
|June 7, 2024
Resumen
Las bacterias intestinales convierten los ácidos biliares en neurosteroides a través de la deshidroxilación 21. Este proceso, que utiliza el hidrógeno ambiental, revela una interacción molecular clave entre los microbios intestinales y la fisiología del huésped.
Área de la Ciencia:
- Microbiología
- Neuroendocrinología
- Las vías metabólicas
Sus antecedentes:
- Los microbios intestinales influyen significativamente en la fisiología del huésped.
- Los mecanismos moleculares subyacentes a las interacciones huésped-comensales no se comprenden completamente.
Objetivo del estudio:
- Para identificar a los actores moleculares clave en las interacciones entre microbios y huéspedes intestinales.
- Para aclarar las vías microbianas involucradas en el metabolismo de esteroides.
Principales métodos:
- Análisis de la capacidad metabólica de los microbios.
- Investigación de las reacciones enzimáticas en el entorno intestinal.
Principales resultados:
- Se encontró que las bacterias intestinales realizan la deshidroxilación 21.
- Esta actividad enzimática microbiana convierte los corticoides biliares en neurosteroides.
- La reacción utiliza el hidrógeno ambiental (H2) como un cofactor fácilmente disponible.
Conclusiones:
- Las bacterias intestinales juegan un papel crucial en la síntesis de neurosteroides.
- La deshidroxilación microbiana de 21 representa una interacción significativa entre el huésped y el comensal.
- Esta vía destaca un nuevo vínculo entre la microbiota intestinal y la neurobiología del huésped.
Videos de Conceptos Relacionados
01:37Neural Regulation
39.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.4K
01:31Neurotransmitters
866
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
866
01:11Enteric Nervous System: Regulation of GI Motor Activity
360
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
360
01:29Bacterial Flora of the Large Intestine
421
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
421
01:29Excitatory and Inhibitory Effects of Neurotransmitters
9.9K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
9.9K
01:30Classification of Neurotransmitters
2.8K
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
2.8K