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Patrones de análisis: roles emergentes de la autoorganización tisular en la salud y la enfermedad

Raul Ramos¹, Benjamin Swedlund², Anand K Ganesan³

¹Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, USA; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA, USA.

|June 21, 2024

Resumen

Los tejidos biológicos se autoorganizan espontáneamente para formar patrones complejos tanto en embriones como en adultos. Esta capacidad de patrón innata es crucial para la homeostasis de los tejidos, la curación y la comprensión de las enfermedades.

Área de la Ciencia:

Biología del desarrollo
Ingeniería de tejidos
La medicina regenerativa

Sus antecedentes:

Las morfologías con patrones surgen durante la embriogénesis a través de la autoorganización celular.
Los patrones complejos también se forman en los tejidos adultos, lo que indica una capacidad universal de autoorganización.
El patrón autoorganizado es fundamental para el desarrollo biológico y la función del tejido.

Objetivo del estudio:

Revisar los principios del patrón de autoorganización en los tejidos embrionarios.
Explorar la aplicación de estos principios en tejidos adultos.
Para discutir el papel del patrón en la homeostasis, la curación, la enfermedad y la biología sintética.

Principales métodos:

Revisión de la literatura sobre los mecanismos de patrones autoorganizados.
Análisis de la formación de patrones en tejidos embrionarios y adultos.
Examen de los estados patológicos relacionados con la autoorganización aberrante.

Principales resultados:

La autoorganización es una propiedad ubicua de los tejidos biológicos, esencial para el desarrollo y la función del tejido adulto.
La generación de patrones espontáneos es parte integral de la homeostasis y la curación de los tejidos.
La autoorganización aberrante contribuye a enfermedades como trastornos inflamatorios de la piel y tumores.

Conclusiones:

Comprender los patrones auto-organizados en los tejidos es clave para la biología regenerativa y la medicina.
Los circuitos moleculares de ingeniería pueden aprovechar estos principios para la biología sintética y el desarrollo de organoides.
Los principios de autoorganización ofrecen un plan para crear patrones biológicos complejos.

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