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Updated: Jun 21, 2025

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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Reordenamiento críptico de la cerulenina en la inhibición covalente de la cetosintasa

Ziran Jiang1, Jeffrey A Chen1, Osama G Mohamed2,3

  • 1Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, United States.

Journal of the American Chemical Society
|July 9, 2024
PubMed
Resumen

La cerulenina, un antibiótico, inhibe la síntesis de ácidos grasos al unirse covalentemente a las cetosintasas. Este estudio revela su mecanismo molecular, que implica una escisión del enlace retro-aldol y un reordenamiento estructural en E. coli FabB y FabF.

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