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Updated: Jun 19, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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Síntesis total de (-) - Rauvomina B a través de una ciclopropanación intramolecular promovida por tensión

Jake M Aquilina1, Ankush Banerjee1, Gabriel N Morais1,2

  • 1Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390, United States.

Journal of the American Chemical Society
|July 23, 2024
PubMed
Resumen

Los investigadores lograron la primera síntesis total de (-) -rauvomina B, un alcaloide indol con un anillo de ciclopropano. La estrategia utilizó la ciclopropanación intramolecular de un precursor tetraciclico de N-sulfoniltriazol, obteniendo la molécula objetivo en 11 pasos.

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