Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Anxiolytic Drugs: Benzodiazepines and Buspirone01:29

Anxiolytic Drugs: Benzodiazepines and Buspirone

623
Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...
623
Electrophilic Aromatic Substitution: Nitration of Benzene01:20

Electrophilic Aromatic Substitution: Nitration of Benzene

5.8K
The nitration of benzene is an example of an electrophilic aromatic substitution reaction. It involves the formation of a very powerful electrophile, the nitronium ion, which is linear in shape. The reaction occurs through the interaction of two strong acids, sulfuric and nitric acid.
5.8K
NMR Spectroscopy of Benzene Derivatives01:34

NMR Spectroscopy of Benzene Derivatives

7.9K
Simple unsubstituted benzene has six aromatic protons, all chemically equivalent. Therefore, benzene exhibits only a singlet peak at δ 7.3 ppm in the 1H NMR spectrum. The observed shift is far downfield because the aromatic ring current strongly deshields the protons. Any substitution on the benzene ring makes the aromatic protons nonequivalent, and the protons split each other. The peak is, therefore, no longer a singlet and the splitting pattern and their associated coupling...
7.9K
Sedatives and Hypnotics Drugs: Benzodiazepines01:19

Sedatives and Hypnotics Drugs: Benzodiazepines

227
Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
227
Nucleophilic Aromatic Substitution: Elimination–Addition01:11

Nucleophilic Aromatic Substitution: Elimination–Addition

4.0K
Simple aryl halides do not react with nucleophiles. However, nucleophilic aromatic substitutions can be forced under certain conditions, such as high temperatures or strong bases. The mechanism of substitution under such conditions involves the highly unstable and reactive benzyne intermediate. Benzyne contains equivalent carbon centers at both ends of the triple bond, each of which is equally susceptible to nucleophilic attack. This 50–50 distribution of products is...
4.0K
Nomenclature of Aromatic Compounds with a Single Substituent01:23

Nomenclature of Aromatic Compounds with a Single Substituent

8.1K
Benzene is the simplest aromatic hydrocarbon or arene. The IUPAC names for simple monosubstituted benzene derivatives are derived by adding the substituent's name as a prefix to the parent benzene. For example, halobenzene, where the halogen could be fluoro (F), chloro (Cl), bromo (Br), and iodo (I).
8.1K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Synthesis and Characterization of an <i>N</i>-Trifluoromethyl 1,4-Azaborine-Based Phosphine Ligand and Its Transition Metal Complexes.

Inorganic chemistry·2026
Same author

A Catalyst-Controlled Divergent Rearomatization of BN-Benzvalene.

Journal of the American Chemical Society·2026
Same author

Positional Isomerization of 1,2-Azaborine through BN-Benzvalene.

Journal of the American Chemical Society·2026
Same author

A Nitrilium-Type <i>N</i>-Heterocyclic Aryne.

Journal of the American Chemical Society·2025
Same author

Boron-Nitrogen-Containing Benzene Valence Isomers.

Chemistry (Weinheim an der Bergstrasse, Germany)·2024
Same author

N-Functionalization of 1,2-Azaborines.

Synlett : accounts and rapid communications in synthetic organic chemistry·2024
Same journal

Carbonylative Aminative Suzuki-Miyaura Coupling: Pd-Catalyzed Synthesis of Amides from Vinyl/Aryl Halides and Boronic Acids.

Journal of the American Chemical Society·2026
Same journal

Divergent Asymmetric Synthesis of Glutinosasins A-E.

Journal of the American Chemical Society·2026
Same journal

Ultrastrong Polyketone Hot-Melt Adhesives Enabled by Ni-Catalyzed Carbonylative Polymerization.

Journal of the American Chemical Society·2026
Same journal

Programmable Anomalous Photovoltaics Enabled by Light-Electric Dual-Field Control.

Journal of the American Chemical Society·2026
Same journal

Biomimetic Redox-Mediated Proton Relay in Nanoreactors for Photocatalysis.

Journal of the American Chemical Society·2026
Same journal

The Sulfur Monoxide-Water Complex.

Journal of the American Chemical Society·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jun 18, 2025

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

2.8K

A BN-bencvaleno

Tomoya Ozaki1, Sierra K Bentley1, Nina Rybansky1

  • 1Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States.

Journal of the American Chemical Society
|July 31, 2024
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores sintetizaron el BN-benzvaleno, el primer benzvaleno con un heteroátomo de segunda fila. Este nuevo compuesto se forma a través de la fotoexcitación de las azaborinas, revelando una vía única de isomerización específica de boro distinta de los análogos de carbono.

Más Videos Relacionados

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics
08:42

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics

Published on: September 19, 2016

8.7K
Closed Chest Biventricular Pressure-Volume Loop Recordings with Admittance Catheters in a Porcine Model
07:56

Closed Chest Biventricular Pressure-Volume Loop Recordings with Admittance Catheters in a Porcine Model

Published on: May 18, 2021

3.6K

Videos de Experimentos Relacionados

Last Updated: Jun 18, 2025

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

2.8K
A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics
08:42

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics

Published on: September 19, 2016

8.7K
Closed Chest Biventricular Pressure-Volume Loop Recordings with Admittance Catheters in a Porcine Model
07:56

Closed Chest Biventricular Pressure-Volume Loop Recordings with Admittance Catheters in a Porcine Model

Published on: May 18, 2021

3.6K

Área de la Ciencia:

  • Química inorgánica sintética
  • La fotoquímica
  • Síntesis orgánica

Sus antecedentes:

  • El benzaleno es un isómero de alta energía del benceno.
  • Las investigaciones anteriores se centraron en los benzvalenos a base de carbono.
  • La incorporación de heteroátomos en sistemas de anillos tensados es de gran interés.

Objetivo del estudio:

  • Para sintetizar y caracterizar el primer heteroatomo de la segunda fila que contiene bencvaleno (BN-bencvaleno).
  • Investigar la vía fotoquímica para la formación de BN-benzvaleno.
  • Para comparar el mecanismo de isomerización con los análogos conocidos de carbono, fósforo y silicio.

Principales métodos:

  • Síntesis de las 1,2-azaborinas C5-arilo sustituidas.
  • Fotoexcitación de las azaborinas en condiciones de flujo.
  • Caracterización cristalográfica del producto.
  • Estudios mecanicistas, incluido el análisis computacional (implicado).

Principales resultados:

  • Síntesis exitosa y caracterización cristalográfica del BN-benzvaleno.
  • El BN-benzvaleno se forma mediante la fotoexcitación de las 1,2-azaborinas.
  • Los estudios mecanicistas indican una vía de fotoisomerización de dos pasos distinta que involucra un intermediario de benceno BN-Dewar.
  • Esta vía difiere de las observadas para el benceno, el fosfa y los silabencenos.

Conclusiones:

  • El BN-benzvaleno representa una nueva clase de moléculas orgánicas tensadas que contienen heteroátomos.
  • La síntesis fotoquímica ofrece una ruta para nuevos compuestos que contienen BN.
  • El mecanismo de fotoisomerización específico de boro identificado amplía nuestra comprensión de los reordenamientos fotoquímicos en sistemas tensos.