Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Gap Junctions01:37

Gap Junctions

52.8K
Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
52.8K
Contact-dependent Signaling01:19

Contact-dependent Signaling

44.5K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
44.5K
Tight Junctions01:29

Tight Junctions

5.2K
Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
5.2K
Plasmodesmata01:20

Plasmodesmata

2.8K
In a multicellular organism, cells must communicate to work together in a coordinated manner. One way that cells communicate is through direct contact with other cells. The points of contact that connect adjacent cells are called intercellular junctions.
Intercellular junctions are a feature of fungal, plant, and animal cells. However, different types of junctions are found in different kinds of cells. Intercellular junctions found in animal cells include tight junctions, gap junctions, and...
2.8K
Aquaporins01:25

Aquaporins

4.8K
Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.
4.8K
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

3.0K
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
3.0K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Fluorinated Ultralong-Acting Neuromuscular Blocking Agent with Improved Activity Profile and Biosafety for the Development of Blockade and Reversal Partner Drugs.

Journal of medicinal chemistry·2026
Same author

Perfluoroalkylated amphiphilic porphyrin nanomicelles for improved photodynamic therapy: anti-tumour efficacy through stability enhancement and O<sub>2</sub> enrichment.

Journal of materials chemistry. B·2026
Same author

Rational guest selection: a general principle for stabilizing multi-component luminescent materials.

Chemical science·2026
Same author

Hierarchical Assembly of Fluorinated BODIPY-Based Nanoribbons for Highly Efficient Metal-Free Photocatalytic Hydrogen Production.

Journal of the American Chemical Society·2026
Same author

Single-Molecule Localization Expansion Nanoscopy via Spontaneously Blinking Fluorophores.

Chemical & biomedical imaging·2026
Same author

Artificial Spherical Chromatophore Mimicking LH2 and LH1-RC for Highly Efficient Photocatalytic Hydrogen Production with Turnover Number >667,000.

Journal of the American Chemical Society·2026

Video Experimental Relacionado

Updated: Jun 17, 2025

Single-cell Microinjection for Cell Communication Analysis
09:59

Single-cell Microinjection for Cell Communication Analysis

Published on: February 26, 2017

11.3K

Canales supramoleculares ensamblados dentro de las brechas intercelulares

Qi Xiao1, Daoming Guan1, Yong-Hong Fu1

  • 1Department of Chemistry, Fudan University, 220 Handan Road, 200433 Shanghai, China.

Journal of the American Chemical Society
|August 8, 2024
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores crearon canales tubulares artificiales en las células para imitar las uniones naturales. Estos canales supramoleculares inhiben la invasión de las células tumorales al bloquear la migración celular, ofreciendo una nueva estrategia de quimioterapia.

Más Videos Relacionados

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
10:46

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

Published on: July 16, 2013

16.3K
An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay
09:47

An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay

Published on: February 1, 2019

7.2K

Videos de Experimentos Relacionados

Last Updated: Jun 17, 2025

Single-cell Microinjection for Cell Communication Analysis
09:59

Single-cell Microinjection for Cell Communication Analysis

Published on: February 26, 2017

11.3K
Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
10:46

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

Published on: July 16, 2013

16.3K
An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay
09:47

An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay

Published on: February 1, 2019

7.2K

Área de la Ciencia:

  • Ciencia de los biomateriales
  • Biología celular
  • Nanotecnología

Sus antecedentes:

  • Las estructuras tubulares son vitales en los sistemas biológicos, mediando la comunicación celular.
  • Los análogos artificiales ofrecen potencial para nuevas estrategias terapéuticas, como en la quimioterapia.
  • Las uniones de huecos naturales proporcionan un plan para construir canales intercelulares funcionales.

Objetivo del estudio:

  • Para construir canales supramoleculares artificiales dentro de las brechas intercelulares.
  • Para imitar el ensamblaje y la estructura de los canales de unión natural.
  • Para investigar el potencial de estos canales artificiales en la inhibición de la invasión de células tumorales.

Principales métodos:

  • Ensamblaje de canales supramoleculares impulsado por interacciones electrostáticas.
  • Imitando la estructura de las uniones naturales con módulos hidrofóbicos e hidrofílicos.
  • Utilizando espacios intercelulares para la construcción de canales.

Principales resultados:

  • Construido con éxito canales supramoleculares dentro de las brechas intercelulares.
  • Los canales imitan los componentes estructurales de las uniones de huecos naturales.
  • Se ha demostrado la inhibición de la invasión de células tumorales mediante la prevención de la migración celular.

Conclusiones:

  • Los canales supramoleculares artificiales se pueden ensamblar en las células vivas.
  • Estos canales inhiben eficazmente la invasión y migración de las células tumorales.
  • Este enfoque representa una nueva estrategia prometedora para la quimioterapia del cáncer.