Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.5K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.5K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
Adult Stem Cells01:33

Adult Stem Cells

28.1K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
28.1K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.0K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones.

Nature·2026
Same author

A high-fat, low-carbohydrate diet can feed intestinal tumours.

Nature·2026
Same author

<i>Clostridioides difficile</i> Stimulates <i>CCL20</i> Expression in Human Colonoid Monolayers in a Transwell-Based Coculture System That Supports Its Anaerobic Growth.

International journal of microbiology·2026
Same author

Impact of vitamin D on the colon cancer immune microenvironment: results of a randomized clinical trial of preoperative vitamin D supplementation in patients with stage I-III colon cancer.

Cancer discovery·2026
Same author

Correction: <sup>1</sup>H-NMR serum metabolomic profiling from clinical routine identifies signatures of progressive melanoma metastasis.

Scientific reports·2026
Same author

Small intestine microbiota development prevents early-life adiposity via IL-22-mediated intestinal PPARα suppression.

bioRxiv : the preprint server for biology·2026

Video Experimental Relacionado

Updated: Jun 15, 2025

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
09:10

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

2.2K

La realimentación a corto plazo después del ayuno mejora la rigidez intestinal a través de las poliaminas

Shinya Imada1, Saleh Khawaled1, Heaji Shin1

  • 1Department of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.

Nature
|August 21, 2024
PubMed
Resumen

La realimentación después del ayuno aumenta la regeneración de las células madre intestinales y la formación de tumores mediante la activación del mTORC1 y el metabolismo de la poliamina. Esto pone de relieve los riesgos potenciales de cáncer en las estrategias de regeneración basadas en la dieta.

Más Videos Relacionados

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
08:55

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Published on: May 18, 2018

10.8K
Real Time Analysis of Metabolic Profile in Ex Vivo Mouse Intestinal Crypt Organoid Cultures
08:53

Real Time Analysis of Metabolic Profile in Ex Vivo Mouse Intestinal Crypt Organoid Cultures

Published on: November 3, 2014

16.2K

Videos de Experimentos Relacionados

Last Updated: Jun 15, 2025

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
09:10

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

2.2K
Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
08:55

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Published on: May 18, 2018

10.8K
Real Time Analysis of Metabolic Profile in Ex Vivo Mouse Intestinal Crypt Organoid Cultures
08:53

Real Time Analysis of Metabolic Profile in Ex Vivo Mouse Intestinal Crypt Organoid Cultures

Published on: November 3, 2014

16.2K

Área de la Ciencia:

  • Biología celular
  • Gastroenterología
  • En el campo de la oncología

Sus antecedentes:

  • Se sabe que los regímenes de ayuno mejoran la salud, la esperanza de vida y la regeneración de los tejidos.
  • El impacto del ayuno y la realimentación en las células madre adultas y la formación de tumores sigue siendo poco explorado.

Objetivo del estudio:

  • Investigar cómo la alimentación posterior al ayuno afecta la proliferación de las células madre intestinales (CIE) y la formación de tumores.
  • Para aclarar los mecanismos moleculares que impulsan estos efectos.

Principales métodos:

  • Se estudiaron los efectos de la alimentación posterior al ayuno en las células madre intestinales Lgr5+ (ISC) en ratones.
  • Investigó el papel de la señalización mTORC1, el metabolismo de la poliamina y la síntesis de proteínas.
  • Incidencia evaluada del tumor en el contexto de la mutación del gen Apc.

Principales resultados:

  • La realimentación posterior al ayuno aumenta significativamente la proliferación de CSI y la formación de tumores.
  • Este efecto está mediado por la inducción de mTORC1, la mejora de la síntesis de proteínas a través del metabolismo de la poliamina.
  • La pérdida del gen supresor del tumor Apc en las CSI refed conduce a una mayor incidencia de tumores.

Conclusiones:

  • La realimentación posterior al ayuno representa un estado fisiológico distinto que promueve la regeneración de las células madre y la tumorigénesis.
  • Las estrategias basadas en la dieta que involucran ayuno y realimentación requieren una cuidadosa consideración para mitigar el riesgo de cáncer.
  • Dirigirse al mTORC1, al metabolismo de las poliaminas o a la síntesis de proteínas puede ofrecer vías terapéuticas.