Video Experimental Relacionado

Updated: Jun 15, 2025

In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells
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Published on: September 2, 2019

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Localización proteica dirigida por reclutamiento covalente 14-3-3

Qian Shao1,2, Tuong Nghi Duong1,2, Inji Park1,2

  • 1Departments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, United States.

Journal of the American Chemical Society
|August 28, 2024
PubMed
Resumen

Los investigadores desarrollaron un nuevo ligando covalente, EN171, que actúa como un pegamento molecular 14-3-3. Esto mejora las interacciones 14-3-3σ con factores de transcripción como YAP y TAZ, lo que permite el secuestro de proteínas dirigidas.

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