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Updated: Jun 14, 2025

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins
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La cascada de fosforilación mediada por PLK1 activa el complejo Mis18 para garantizar la herencia del centrómero

Pragya Parashara1, Bethan Medina-Pritchard1, Maria Alba Abad1

  • 1Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK.

Science (New York, N.Y.)
|September 5, 2024
PubMed
Resumen

El complejo Mis18, crucial para la identidad del centrómero, es fosforilado por PLK1. Esta fosforilación permite la carga de CENP-A, asegurando una segregación y herencia cromosómicas precisas.

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