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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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La metformina ralentiza el reloj de envejecimiento en monos machos

Yuanhan Yang1, Xiaoyong Lu2, Ning Liu3

  • 1Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Membrane Biology, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Cell
|September 13, 2024
PubMed
Resumen

La metformina demostró efectos geroprotectores en un estudio de envejecimiento en primates, disminuyendo significativamente los indicadores del envejecimiento biológico. Esta investigación muestra que la metformina

Palabras clave:
envejecimientoreloj de envejecimientoy metforminaLos primates también.envejecimiento

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Área de la Ciencia:

  • Gerontología e investigación del envejecimiento de los primates.
  • Neurociencia y neuroprotección.
  • Farmacología y desarrollo de fármacos.

Sus antecedentes:

  • La investigación sobre el envejecimiento en primates no humanos es limitada.
  • Los posibles efectos geroprotectores de la metformina requieren una mayor investigación en modelos de primates.
  • Comprender el impacto de la metformina en los fenotipos relacionados con la edad es crucial para las intervenciones en el envejecimiento humano.

Objetivo del estudio:

  • Evaluar los efectos geroprotectores de la metformina en monos cynomolgus machos adultos durante más de 40 meses.
  • Investigar la influencia de la metformina en el envejecimiento del organismo utilizando un enfoque multiómico.
  • Evaluar el impacto neuroprotector de la metformina y sus mecanismos subyacentes.

Principales métodos:

  • Estudio longitudinal que incluye evaluaciones fisiológicas, por imágenes, histológicas y moleculares.
  • Aplicación de la transcriptómica pan-tejida, la metilómica del ADN, la proteómica plasmática y la metabolómica.
  • Desarrollo y utilización de nuevos relojes de envejecimiento de primates para medir los efectos de la metformina.

Principales resultados:

  • La metformina ralentizó significativamente múltiples fenotipos relacionados con la edad a nivel del organismo.
  • Se observó una regresión notable de aproximadamente 6 años en el envejecimiento cerebral.
  • La metformina demostró efectos neuroprotectores, preservando la estructura cerebral y mejorando la función cognitiva.
  • Los efectos geroprotectores en las neuronas fueron mediados en parte por la activación de Nrf2.

Conclusiones:

  • La metformina reduce sistemáticamente la edad biológica multidimensional en los primates.
  • El estudio proporciona evidencia de las capacidades neuroprotectoras y geroprotectoras de la metformina en un modelo de primates.
  • Esta investigación allana el camino para estrategias farmacéuticas dirigidas al envejecimiento humano.