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Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
158
CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

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Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
127
Altered States of Awareness01:06

Altered States of Awareness

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Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
157
Ethics in Research01:56

Ethics in Research

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Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Video Experimental Relacionado

Updated: Jun 12, 2025

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
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HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

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La investigación psicodélica en una encrucijada

Stacey B Armstrong1, Alan K Davis2

  • 1Stacey B. Armstrong is a senior researcher and associate director at the Center for Psychedelic Drug Research and Education, College of Social Work, The Ohio State University, Columbus, OH, USA.

Science (New York, N.Y.)
|September 19, 2024
PubMed
Resumen
Este resumen es generado por máquina.

La terapia asistida con psicodélicos (PAT) es prometedora para la salud mental, pero se enfrenta a preguntas sobre su seguridad y eficacia. Abordar los desafíos de la investigación es crucial para desarrollar tratamientos basados en la evidencia.

Área de la Ciencia:

  • La neurociencia
  • La psiquiatría
  • Psicología clínica

Sus antecedentes:

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  • Las condiciones de salud mental afectan a 1 de cada 8 en todo el mundo, lo que requiere tratamientos novedosos.
  • La terapia asistida por psicodélicos (PAT), que combina psicodélicos con psicoterapia, está siendo investigada en ensayos clínicos.
  • Los psicodélicos alteran la actividad cerebral y la conciencia, ofreciendo beneficios terapéuticos potenciales.