Video Experimental Relacionado

Updated: Jun 12, 2025

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

Mecanismos de la COVID larga y el camino hacia la terapéutica

Michael J Peluso¹, Steven G Deeks¹

¹Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.

|September 26, 2024

Resumen

El COVID largo, una condición post-viral, presenta síntomas médicamente inexplicables después de la infección por SARS-CoV-2. La investigación actual define sus mecanismos, pero faltan tratamientos efectivos, lo que requiere una mayor inversión en ensayos clínicos.

Área de la Ciencia:

Enfermedades infecciosas
Inmunología
Neurología

Sus antecedentes:

El COVID largo, o secuelas post-agudas del SARS-CoV-2 (PASC), es una condición crónica recientemente reconocida que causa discapacidad.
Millones se ven afectados por el Long COVID, sin embargo, las terapias efectivas son limitadas, con una participación mínima de la industria.
Se han hecho avances significativos en la comprensión de su epidemiología, biología y fisiopatología.

Objetivo del estudio:

Revisar el conocimiento actual sobre la biología y la fisiopatología de Long COVID.
Para explorar cómo los mecanismos propuestos explican la fisiología del síndrome.
Proporcionar una justificación para la medicina experimental y los ensayos clínicos.

Principales métodos:

Revisión de la literatura sobre las investigaciones actuales sobre el COVID largo.
Análisis de los mecanismos biológicos y fisiopatológicos propuestos.
Síntesis de los hallazgos para el diseño de futuras investigaciones y ensayos clínicos.

Principales resultados:

El COVID prolongado implica síntomas complejos y médicamente inexplicables después de la infección por SARS-CoV-2.
Comprender los mecanismos subyacentes es crucial para desarrollar terapias dirigidas.
Se necesita una amplia agenda de medicina experimental y ensayos clínicos.

Conclusiones:

A pesar de los avances en la definición del COVID largo, una cura sigue siendo difícil de alcanzar.
El desarrollo de tratamientos efectivos requiere una inversión sustancial y sostenida de los financiadores y la industria.
Es esencial seguir investigando las enfermedades crónicas asociadas a las infecciones.

Palabras clave:

El COVID-19 COVID largo Condición después del COVID-19 Síndrome post-agudo por el COVID-19 las secuelas post-agudas de la infección por SARS-CoV-2

Más Videos Relacionados

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

Published on: December 23, 2020

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

Videos de Conceptos Relacionados

COPD: Pathogenesis and Clinical Features

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

Myocarditis III: Medical Management

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.