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Acoplamiento y activación del receptor adrenérgico β1 - El papel del tercer bucle intracelular

Xingyu Qiu1,2, Kin Chao3, Siyuan Song1,2

  • 1Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3QZ, U.K.

Journal of the American Chemical Society
|October 3, 2024
PubMed
Resumen

El bucle intracelular 3 (ICL3) del receptor adrenérgico β1 (β1AR) mejora la señalización de la proteína G al alterar sutilmente la unión de Gs después de la liberación de nucleótidos, aumentando la producción de cAMP pero no la liberación de GDP.

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