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Updated: Jun 15, 2026

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
10:12

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols

Published on: April 4, 2014

Reacción catalítica asimétrica de Barbier de cetonas con electrófilos alquilo no activados

Hanyu Xia1, Xingni Jiang1, Di Lin1

  • 1Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China.

Journal of the American Chemical Society
|October 3, 2024
PubMed
Resumen

Este estudio introduce una nueva reacción de tipo Barbier catalizada por cobalto para crear alcoholes terciarios quirales complejos a partir de cetonas y haluros de alquilo. Este método eficiente permite la síntesis de centros estereogénicos tetrasubstituidos desafiantes, incluso para el medicamento Sofdra.

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