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Updated: Jun 10, 2025

Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
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Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes

Published on: July 28, 2018

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Difluorometilación altamente descarboxilada y enantioselectiva

Xian Zhao1, Chao Wang1, Lingfeng Yin1

  • 1Department of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, United States.

Journal of the American Chemical Society
|October 15, 2024
PubMed
Resumen

Los investigadores desarrollaron una nueva reacción catalizada por níquel para crear moléculas difluorometiladas enantioselectivas a partir de ácidos carboxílicos. Este método instala de manera eficiente los grupos difluorometilo (CF2H), que son cruciales para las aplicaciones farmacéuticas.

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