Video Experimental Relacionado
Updated: Jun 10, 2025
07:42
Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
Published on: September 17, 2016
12.8K
La plasticidad circadiana evoluciona a través de cambios regulatorios en un gen de neuropéptido
Michael P Shahandeh1,2, Liliane Abuin3, Lou Lescuyer De Decker3
1Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. Michael.P.Shahandeh@hofstra.edu.
Nature
|October 16, 2024
Resumen
El gen del factor de dispersión del pigmento del neuropéptido (Pdf)
Área de la Ciencia:
- Biología evolutiva
- Cronología
- La genética
Sus antecedentes:
- La plasticidad circadiana, la capacidad de ajustar los patrones de actividad diaria a los ciclos de luz, es común en muchos organismos.
- La evolución de este rasgo y su base genética siguen siendo poco conocidas.
- Drosophila melanogaster exhibe plasticidad circadiana, mientras que la especialista Drosophila sechellia ha perdido esta capacidad.
Objetivo del estudio:
- Investigar los mecanismos genéticos que subyacen a la evolución de la plasticidad circadiana.
- Para comparar el papel del gen del factor de dispersión de pigmento neuropéptido (Pdf) en la plasticidad circadiana entre Drosophila melanogaster y Drosophila sechellia.
Principales métodos:
- Análisis comparativo de las especies Drosophila melanogaster y Drosophila sechellia.
- Cribado de mutantes circadianos en híbridos entre especies.
- Interferencia de ARN y experimentos de rescate en Drosophila melanogaster.
- Análisis de la divergencia cis-reguladora y las señales de selección en el gen Pdf.
Principales resultados:
- El gen del factor de dispersión del pigmento neuropéptido (Pdf) contribuye a la pérdida de la plasticidad circadiana en Drosophila sechellia.
- La expresión temporal específica de la especie de Pdf, impulsada por la divergencia cis-regulatoria, influye en la plasticidad del comportamiento.
- La región reguladora Pdf muestra signos de selección en ambas especies, correlacionándose con la latitud y la especialización.
- La plasticidad circadiana proporciona una ventaja selectiva para Drosophila melanogaster en latitudes más altas.
Conclusiones:
- El gen Pdf es un locus clave para la evolución de la plasticidad circadiana.
- La divergencia en la regulación del Pdf ha dado forma a la distribución y especialización de las especies de Drosophila.
- Comprender el papel de Pdf arroja luz sobre la adaptación a diferentes entornos de luz y especiación.
Más Videos Relacionados
Videos de Conceptos Relacionados
02:19Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
02:45Biological Clocks and Seasonal Responses
34.6K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
34.6K
01:28Global Regulatory Systems
2
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
2
01:01Neuroplasticity
303
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
303
01:29Somatic to iPS Cell Reprogramming
2.2K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.2K
01:02The Pineal Gland
1.7K
The pineal gland, a diminutive endocrine structure named for its pinecone-shaped appearance, is situated atop the third ventricle within the diencephalon region of the forebrain. This gland, composed of secretory cells known as pinealocytes arranged in compact cords and clusters around dense particles of calcium salts, plays a pivotal role in hormonal regulation.
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
1.7K