Video Experimental Relacionado

Updated: Jun 9, 2025

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

Los viejos 'relojes' luchan por la gloria y el dinero de la ciencia

Science (New York, N.Y.)

|October 24, 2024

Resumen

Este concurso se centra en el avance de ensayos moleculares críticos para evaluar la efectividad de las intervenciones de envejecimiento. Los ensayos mejorados acelerarán el desarrollo y la validación de nuevos tratamientos dirigidos al proceso de envejecimiento.

Área de la Ciencia:

Biotecnología y Biología Molecular
Gerontología e Investigación del Envejecimiento

Sus antecedentes:

Los ensayos moleculares actuales para tratamientos de envejecimiento carecen de la precisión y el rendimiento requeridos para una validación robusta.
El campo del envejecimiento necesita biomarcadores estandarizados y confiables para evaluar la eficacia terapéutica.

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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...

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