Video Experimental Relacionado

Updated: Jun 9, 2025

A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer SMPS-ICPMS

A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer SMPS-ICPMS

Published on: July 11, 2017

Espectrometría de masa de plasma acoplada inductivamente (ICP-MS): una herramienta emergente en la ciencia

Karel D Klika¹, Jianlin Han², Marvin S Busse³

¹Molecular Structure Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

Journal of the American Chemical Society

|October 31, 2024

Resumen

Los ensayos de espectrometría de masas de plasma acoplado inductivamente no radiactivo (ICP-MS) ofrecen una alternativa rentable y accesible a los métodos radiactivos tradicionales en la investigación radiofarmacéutica. Este enfoque minimiza las desventajas asociadas con la radiactividad en el descubrimiento de fármacos y la investigación del cáncer.

Área de la Ciencia:

Química analítica
Ciencias radiofarmacéuticas
Investigación del cáncer

Sus antecedentes:

Los experimentos radiactivos son cruciales pero costosos, requieren instalaciones especializadas y se enfrentan a obstáculos regulatorios.
El desarrollo de alternativas no radiactivas es esencial para avanzar en el descubrimiento de fármacos radiofármacos y en la investigación sobre el cáncer terapéutico.
La espectrometría de masa de plasma acoplada inductivamente (ICP-MS) presenta una técnica analítica no radiactiva prometedora.

Objetivo del estudio:

Destacar el desarrollo y la aplicación de ensayos basados en ICP-MS no radiactivos.
Presentar el ICP-MS como una alternativa viable a los métodos radiactivos en la investigación radiofarmacéutica.
Fomentar la investigación en técnicas no radiactivas para la detección del cáncer y el descubrimiento de fármacos.

Principales métodos:

Se centrará en la aplicación de la espectrometría de masas de plasma acoplada inductivamente (ICP-MS).
Discutir el diseño y la validación de ensayos ICP-MS no radiactivos.
Revisar los avances recientes en el ICP-MS para el análisis radiofarmacéutico.

Principales resultados:

El ICP-MS proporciona una potente plataforma no radioactiva para el análisis cuantitativo en la investigación radiofarmacéutica.
Las aplicaciones prácticas de ICP-MS en este campo se están expandiendo rápidamente.
Los ensayos no radiactivos reducen los costes, los requisitos de las instalaciones y las restricciones en comparación con los métodos tradicionales.

Conclusiones:

Los ensayos ICP-MS no radiactivos son un avance significativo en la investigación radiofarmacéutica.
Esta tecnología ofrece una alternativa práctica y beneficiosa a los enfoques radiactivos.
Una mayor exploración del ICP-MS acelerará la innovación en la teranostica del cáncer y el descubrimiento de fármacos.

Más Videos Relacionados

Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications

Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications

Published on: April 21, 2022

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry LA-ICP-MS

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry LA-ICP-MS

Published on: January 22, 2017

Videos de Conceptos Relacionados

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...

Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle

Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle

Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...

Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation

Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation

Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
There are three main types of inductively coupled plasma atomic emission spectroscopy (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used....

Atomic Emission Spectroscopy: Lab

Atomic Emission Spectroscopy: Lab

AES is a powerful analytical technique, especially effective when used with plasma sources, producing abundant spectra in characteristic emission lines. The Inductively Coupled Plasma (ICP), in particular, yields superior quantitative analytical data due to its high stability, low noise, low background, and minimal interferences under optimal experimental conditions. However, newer air-operated microwave sources are emerging as promising alternatives that could be more cost-effective than...

Tandem Mass Spectrometry

Tandem Mass Spectrometry

Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and signal-to-noise ratio for the analyte. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.
Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called collision-induced...