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Los aferentes vagales hepáticos transmiten señales dependientes del reloj para regular la ingesta de alimentos
Lauren N Woodie1,2, Lily C Melink1,2, Mohit Midha1,2
1Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Science (New York, N.Y.)
|November 7, 2024
Resumen
Los ritmos circadianos alterados perjudican la salud metabólica. El hígado señala la disfunción del reloj cerebral a través del nervio aferente vagal hepático (HVAN), afectando la ingesta de alimentos, una vía dirigida para el tratamiento de la obesidad.
Área de la Ciencia:
- Cronología
- La neurociencia
- Salud metabólica
Sus antecedentes:
- La desincronización circadiana del trabajo por turnos o el jet lag tiene un impacto negativo en la salud metabólica.
- Los mecanismos de comunicación entre los tejidos en respuesta a la interrupción circadiana son poco conocidos.
Objetivo del estudio:
- Para investigar cómo la disfunción del reloj molecular del hígado envía señales al cerebro.
- Para identificar las vías neuronales involucradas en la transmisión de estas señales.
- Explorar objetivos terapéuticos para la obesidad relacionados con la interrupción circadiana.
Principales métodos:
- Inducción de la disfunción del reloj molecular del hígado.
- Ablación del nervio aferente vagal hepático (NAVH).
- Evaluación de los patrones de ingesta de alimentos y los cambios en el peso corporal.
- Modelos de alimentación con alto contenido de grasa.
Principales resultados:
- La disfunción del reloj del hígado envía señales al cerebro a través del HVAN.
- La ablación HVAN corrige los patrones alterados de ingesta de alimentos causados por la disfunción del reloj hepático.
- La vagotomía hepática mitiga las interrupciones de la ingesta de alimentos y reduce el aumento de peso de las dietas altas en grasas.
Conclusiones:
- Existe una señal de retroalimentación homeostática entre el hígado y el cerebro, mediada por el HVAN, para regular la ingesta de alimentos circadianos.
- El nervio vago hepático es un objetivo terapéutico potencial para la obesidad en individuos con trastornos circadianos.
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