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Compartición de cepas del microbioma intestinal dentro de las redes sociales de las aldeas aisladas
Francesco Beghini1, Jackson Pullman1,2, Marcus Alexander1
1Yale Institute for Network Science, Yale University, New Haven, CT, USA.
Nature
|November 20, 2024
Resumen
Las redes sociales humanas dan forma a los microbiomas intestinales a través del intercambio microbiano, incluso más allá de la familia cercana. Los individuos socialmente centrales tienen bacterias intestinales más diversas, lo que refleja sus conexiones comunitarias más amplias.
Área de la Ciencia:
- Microbiología
- Epidemiología social
- Ciencia de las redes
Sus antecedentes:
- Las interacciones sociales humanas crean entornos para el intercambio microbiano.
- La composición del microbioma intestinal está influenciada por factores sociales y ambientales.
Objetivo del estudio:
- Investigar la relación entre la estructura de la red social y la composición del microbioma intestinal.
- Explorar el intercambio microbiano a través de diferentes tipos de relaciones y grados de red.
Principales métodos:
- Mapeo de redes sociales y secuenciación del microbioma en 1.787 adultos en 18 aldeas.
- Análisis de los datos microbianos a nivel de especie y cepa.
- Análisis longitudinal del microbioma de 301 individuos durante dos años.
Principales resultados:
- El intercambio microbiano se observó en varias conexiones sociales, incluidos los lazos no familiares.
- El intercambio de tensiones se extendió a las conexiones sociales de segundo grado, destacando una influencia de red más amplia.
- Los individuos socialmente centrales exhibieron una mayor similitud microbiana con su población de la aldea.
- Los individuos conectados mostraron una mayor convergencia en el reparto de cepas a lo largo del tiempo en comparación con los individuos no conectados.
Conclusiones:
- Las redes sociales estructuran el microbioma intestinal, influyendo en la diversidad y composición microbiana.
- Las conexiones sociales, más allá del hogar y la familia, facilitan un intercambio microbiano significativo.
- Las redes sociales actúan como nichos ecológicos que dan forma a la biología del microbioma y sus efectos fenotípicos.
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