Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Tissues01:18

Tissues

70.2K
Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
70.2K
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

3.4K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.4K
Structural Organization of the Human Body: An Overview01:18

Structural Organization of the Human Body: An Overview

29.2K
It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
29.2K
Tissues01:25

Tissues

63.6K
Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...
63.6K
Embryonic Connective Tissues01:20

Embryonic Connective Tissues

6.8K
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
6.8K
Bone Cells and Tissue01:30

Bone Cells and Tissue

12.5K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
12.5K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

High-Risk Rhabdomyosarcomas Feature a Convergent Cell State.

Cancer research·2026
Same author

Inherited human TFIIIA deficiency disrupts T cell development.

medRxiv : the preprint server for health sciences·2026
Same author

Human embryonic stem cell-derived dopaminergic cells for Parkinson's disease: a phase 1/2 open-label trial.

Nature medicine·2026
Same author

Heterogeneity and dynamics of DENV-specific CD8 + T cells in dengue infection.

Nature communications·2026
Same author

A Hormone Cell Atlas maps the human endocrine system at cellular resolution.

Science (New York, N.Y.)·2026
Same author

Editorial: Silent But Detectable-High-Throughput Proteomics to Identify Clinically Significant Liver Disease.

Alimentary pharmacology & therapeutics·2026

Video Experimental Relacionado

Updated: May 2, 2026

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
08:21

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

Published on: October 2, 2018

6.7K

Un atlas espacial de células del timo humano mapeado a un eje de tejido continuo

Nadav Yayon1,2,3, Veronika R Kedlian1,3, Lena Boehme4

  • 1Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK.

Nature
|November 20, 2024
PubMed
Resumen

Los investigadores mapearon el desarrollo del timo humano utilizando un nuevo marco, revelando el establecimiento temprano de vías y nichos de células inmunes en el segundo trimestre. Este trabajo mejora la comprensión del desarrollo de células T y ofrece un conjunto de herramientas para el análisis de tejidos.

Más Videos Relacionados

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
11:00

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

17.0K
Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids
03:31

Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids

Published on: October 4, 2024

1.4K

Videos de Experimentos Relacionados

Last Updated: May 2, 2026

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
08:21

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

Published on: October 2, 2018

6.7K
Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
11:00

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

17.0K
Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids
03:31

Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids

Published on: October 4, 2024

1.4K

Área de la Ciencia:

  • Inmunología del desarrollo
  • Morfología del tejido
  • Biología unicelular

Sus antecedentes:

  • El desarrollo de células T ocurre en el timo, un proceso activo desde las etapas fetales hasta la adolescencia.
  • Comprender la microanatomía del timo es crucial para estudiar la maduración y selección de las células T.

Objetivo del estudio:

  • Mapear las estructuras microanatómicas que apoyan el desarrollo de las células T en las primeras etapas fetales y posnatales humanas.
  • Analizar la organización espacial de los componentes tímicos y las trayectorias de los timocitos.

Principales métodos:

  • Se ha establecido un marco morfológico cuantitativo (eje córtico-medular) para el análisis del timo.
  • Aplicó el marco al atlas multimodal de una sola célula, la transcriptómica espacial y los datos de imagen múltiple.
  • Desarrolló un kit de herramientas (TissueTag) para el análisis de datos de imágenes multiplataforma y la construcción de OrganAxis.

Principales resultados:

  • Establecimiento demostrado de la red de citoquinas lobulares, trayectorias de timocitos y distribuciones de células epiteliales del timo en el segundo trimestre del desarrollo fetal.
  • Nichos progenitoras identificados para las células epiteliales del timo y subtipos asociados con los corpúsculos de Hassall.
  • Se reveló el momento diferencial de entrada medular para los linajes de células T CD4 y CD8.

Conclusiones:

  • El estudio proporciona un mapa detallado del desarrollo temprano del timo humano y la maduración de los linfocitos T.
  • Los hallazgos ofrecen información sobre el establecimiento de nichos de células inmunes y trayectorias de desarrollo.
  • El kit de herramientas desarrollado (TissueTag) facilita el análisis de arquitecturas de tejidos complejos en varios conjuntos de datos.