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Updated: Jun 2, 2025

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
11:02

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Published on: September 14, 2018

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Coacervados sensibles a la reacción de Staudinger para el suministro de anticuerpos citosólicos y la degradación de

Yishu Bao1, Zhiyi Xu1, Kai Cheng1

  • 1Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR 99999, China.

Journal of the American Chemical Society
|January 13, 2025
PubMed
Resumen

Los investigadores desarrollaron Coacervados Staudinger-Reacción-Responsivos (SR-Coa) para la administración de proteínas dirigidas a las células. Estos coacervados liberan su carga de proteínas en el citosol al reaccionar con azidas, lo que permite aplicaciones como la degradación de proteínas dirigidas.

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