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Los beneficios cardiometabólicos de una dieta de tipo no industrializado están relacionados con la modulación del

Fuyong Li¹, Anissa M Armet², Katri Korpela³

¹Department of Agricultural, Food & Nutritional Science, University of Alberta, Edmonton, AB T6G 2E1, Canada; Department of Animal Science and Technology, College of Animal Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.

|January 24, 2025

Resumen

Una dieta de restauración, imitando patrones de alimentación no industrializados, mejoró la salud intestinal y los marcadores cardiometabólicos en adultos. Este enfoque dietético es prometedor para prevenir enfermedades crónicas relacionadas con cambios en el microbioma intestinal.

Área de la Ciencia:

Investigación del microbioma
Ciencias de la nutrición
Prevención de las enfermedades crónicas

Sus antecedentes:

La industrialización tiene un impacto negativo en el microbioma intestinal, aumentando el riesgo de enfermedades crónicas no transmisibles.
La restauración de los estados ancestrales del microbioma puede contrarrestar estos efectos adversos.

Objetivo del estudio:

Evaluar una estrategia de restauración del microbioma utilizando una "dieta de restauración" y Limosilactobacillus reuteri.
Evaluar el impacto en la composición del microbioma intestinal y la salud cardiometabólica del huésped.

Principales métodos:

Un ensayo aleatorio controlado de alimentación en adultos canadienses sanos.
La intervención incluyó una "dieta de recuperación" y/o Limosilactobacillus reuteri (PB-W1).
Se analizaron los cambios en el microbioma intestinal, los metabolitos plasmáticos y los parámetros cardiometabólicos.

Principales resultados:

La "dieta de restauración" mejoró la persistencia de L. reuteri y corrigió las alteraciones del microbioma inducidas por la industrialización.
Se observaron cambios beneficiosos en los metabolitos plasmáticos derivados de la microbiota asociados con la etiología de la enfermedad crónica.
Los beneficios cardiometabólicos significativos se produjeron independientemente de L. reuteri, predichos por las características del microbioma.

Conclusiones:

Las intervenciones dietéticas dirigidas a la restauración del microbioma intestinal pueden mejorar las interacciones huésped-microbioma.
Esta estrategia tiene potencial para orientar las recomendaciones dietéticas y desarrollar enfoques nutricionales terapéuticos para enfermedades crónicas.

Palabras clave:

Limosilactobacillus reuteri y sus derivados Salud cardiometabólica Enfermedad crónica el régimen alimenticio Intervención dietética Las fibras El microbioma intestinal Restauración del microbioma Dieta no industrializada La nutrición

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