Video Experimental Relacionado

Updated: Jun 13, 2025

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

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La activación de GUK1 es una responsabilidad metabólica en el cáncer de pulmón

Jaime L Schneider1, Kiran Kurmi2, Yutong Dai3

  • 1Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA, USA.

Cell
|February 7, 2025
PubMed
Resumen

La señalización de la Linfoma Anaplásica Kinasa (ALK) en el cáncer de pulmón impulsa la fosforilación de la guanilata quinasa 1 (GUK1), aumentando la síntesis de difosfato de guanosina (GDP). Dirigirse a GUK1 puede ofrecer nuevas estrategias terapéuticas para los cánceres de pulmón impulsados por oncogenes.

Palabras clave:
Cantidad totalEl PIBGUK1Señalización RasSin embargo, los pacientes con linfoma anaplásicometabolismo del cáncerGuanilato quinasa 1 y sus derivadosCáncer de pulmónCáncer de pulmón de células no pequeñasInhibidor de la tirosina quinasa

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