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Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Liver Physiology01:30

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
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Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
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Ovarian Cycle01:27

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The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
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Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

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The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
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Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

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The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
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Video Experimental Relacionado

Updated: May 28, 2025

The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy
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The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy

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El embarazo y el hígado

Mussarat N Rahim1, Catherine Williamson2, Nikos A Kametas3

  • 1Institute of Liver Studies, King's College Hospital National Health Services Foundation Trust, London, UK; Fetal Medicine Research Unit, King's College Hospital National Health Services Foundation Trust, London, UK.

Lancet (London, England)
|February 8, 2025
PubMed
Resumen

El embarazo causa cambios fisiológicos en el hígado, que afectan a las enfermedades hepáticas existentes y conducen a nuevas condiciones. Comprender estos cambios hepáticos es crucial para gestionar los riesgos materno-fetal y la salud futura.

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Área de la Ciencia:

  • Hepatología
  • Obstetricia y parto
  • Médico interno

Sus antecedentes:

  • El embarazo implica alteraciones fisiológicas en el hígado.
  • Las enfermedades hepáticas preexistentes pueden agravarse o mejorar.
  • Pueden surgir trastornos hepáticos específicos del embarazo.

Objetivo del estudio:

  • Revisar el diagnóstico de la enfermedad hepática, la estratificación del riesgo y el tratamiento durante el embarazo.
  • Explorar los factores que influyen en la salud materna después del embarazo.
  • Para resaltar la importancia de la atención multidisciplinaria.

Principales métodos:

  • Revisión de la literatura sobre los cambios fisiológicos en el embarazo que afectan al hígado.
  • Análisis de los impactos en las afecciones hepáticas preexistentes y específicas del embarazo.
  • Discusión de los desafíos en el diagnóstico y la gestión.

Principales resultados:

  • Aumento de la prevalencia de embarazos con cirrosis y después del trasplante.
  • Incidencia creciente de trastornos hipertensivos y diabetes gestacional.
  • Necesidad de comprender los cambios hepáticos para el manejo multidisciplinario.

Conclusiones:

  • Las anomalías hepáticas en el embarazo requieren conocimientos especializados.
  • El aporte multidisciplinario es vital para mitigar los riesgos materno-fetal.
  • El embarazo ofrece oportunidades para intervenciones de salud a largo plazo.