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Un papel crucial para la amígdala cortical en la configuración de encuentros sociales
Antonio V Aubry1,2,3, Romain Durand-de Cuttoli1,2,3, Elizabeth Karpman1,2,3
1Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Nature
|February 12, 2025
Resumen
Los investigadores identificaron células cerebrales específicas en ratones machos que impulsan el comportamiento agresivo. La inhibición de estas células redujo la agresión y aumentó la investigación social, destacando un circuito neuronal clave para la agresión.
Área de la Ciencia:
- La neurociencia
- Biología del comportamiento
- La genética
Sus antecedentes:
- La agresión es un comportamiento conservado crucial para las jerarquías sociales y la protección de los recursos.
- El comportamiento agresivo en ratones incluye las fases de apetito (enfoque) y consumo (ataque).
Objetivo del estudio:
- Para identificar las regiones del cerebro y los circuitos neuronales involucrados en la agresión masculina.
- Para investigar el papel de células específicas en la amígdala cortical posterolateral (COApl) en el comportamiento agresivo.
Principales métodos:
- Análisis sin supervisión de la red de correlación ponderada de la expresión de FOS en todo el cerebro en ratones.
- Manipulación quimiogenética y optogenética de las células que expresan el receptor de estrógeno COApl 1 (Esr1) (COAplEsr1).
- Análisis de las proyecciones de COAplEsr1 hacia el hipotálamo ventromedial y la amígdala central.
Principales resultados:
- Un grupo de regiones cerebrales, incluidas las áreas corticales hipotalámicas, amígdalas y olfativas, mostraron co-activación en agresores masculinos.
- Las células COAplEsr1 fueron altamente activas durante el comportamiento de ataque y la investigación previa en los machos.
- La inhibición de las células COAplEsr1 redujo la agresión y aumentó la investigación pro-social sin afectar la recompensa social.
Conclusiones:
- Las células COAplEsr1 actúan como un centro, respondiendo a los estímulos sociales para promover la agresión en ratones machos.
- Las proyecciones de COAplEsr1 al hipotálamo ventromedial y la amígdala central son críticas para la agresión.
- Estos hallazgos revelan un mecanismo neuronal específico subyacente a la agresión masculina.
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