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Updated: Jun 27, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

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Published on: June 8, 2014

LGR4 (GPR48): El puente emergente en la osteoinmunología

Wonbong Lim^1,2,3,4

¹Department of Orthopaedic Surgery, Chosun University, Gwangju 61453, Republic of Korea.

|March 28, 2025

El receptor acoplado a proteínas G con repeticiones ricas en leucina 4 (LGR4), un miembro de la familia de los receptores acoplados a proteínas G (GPCR), se ha implicado en diversas funciones reguladoras a través de múltiples etapas de diferenciación y numerosos sitios diana en enfermedades óseas. Por lo tanto, el LGR4 es un regulador potencial del ligando del factor nuclear κB (RANKL) durante la diferenciación de los osteoclastos. Sin embargo, se carece de una investigación exhaustiva sobre sus funciones y aplicaciones en la inmunología ósea. Esta revisión analiza las características moleculares, las vías de señalización y el papel del LGR4 en la osteoinmunología, con un enfoque particular en sus interacciones con el RANKL durante la diferenciación de los osteoclastos, al tiempo que identifica las lagunas que justifican investigaciones adicionales.

El receptor acoplado a proteínas G con repeticiones ricas en leucina 4 (LGR4), un miembro de la familia de los receptores acoplados a proteínas G (GPCR), se ha implicado en diversas funciones reguladoras a través de múltiples etapas de diferenciación y numerosos sitios diana en enfermedades óseas. Por lo tanto, el LGR4 es un regulador potencial del ligando del factor nuclear κB (RANKL) durante la diferenciación de los osteoclastos. Sin embargo, se carece de una investigación exhaustiva sobre sus funciones y aplicaciones en la inmunología ósea. Esta revisión analiza las características moleculares, las vías de señalización y el papel del LGR4 en la osteoinmunología, con un enfoque particular en sus interacciones con el RANKL durante la diferenciación de los osteoclastos, al tiempo que identifica las lagunas que justifican investigaciones adicionales.

Palabras clave:

receptor acoplado a proteína G 4 que contiene repeticiones ricas en leucina osteoclastos osteoporosis osteoprotegerina ligando del activador del receptor del factor nuclear kappa-B

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