Video Experimental Relacionado

Updated: May 13, 2025

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
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Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

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La unión al ADN y la fosforilación mitótica protegen las proteínas de la poliglutamina de la formación de ensamblajes

Shady Saad1, Tomek Swigut1, Saman Tabatabaee1

  • 1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Cell
|April 16, 2025
PubMed
Resumen

Los largos tractos de poliglutamina (polyQ) en los factores de transcripción como FOXP2 se mantienen solubles mediante la unión al ADN o la fosforilación. Los cambios humanos específicos en FOXP2 reducen su agregación, ofreciendo información terapéutica para las enfermedades de poliQ.

Palabras clave:
En el caso de los vehículos de motor:La enfermedad de HuntingtonAmiloide y sus derivadosLa evoluciónProteínas ricas en glutaminalenguaje humanolenguajeLa poliglutamina también tiene un efecto secundario.ensamblajes de proteínasFactores de transcripción

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