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Updated: Jun 16, 2025

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

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Endocitosis mediada por CD36 de las quimeras dirigidas a la proteólisis

Zhengyu Wang1, Bo-Syong Pan2, Rajesh Kumar Manne2

  • 1Department of Pharmacology, The Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Department of Pharmaceutical Science, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Cell
|April 18, 2025
PubMed
Resumen

Los investigadores descubrieron que la proteína CD36 facilita la absorción de fármacos grandes como las quimeras dirigidas a la proteólisis (PROTAC). La modificación de los PROTAC para unirse a CD36 mejora su eficacia antitumoral al mejorar la permeabilidad y solubilidad celular.

Palabras clave:
La ADMEEl CD36Las moléculas ERO5 y BRO5Protección de la salud públicacaptación celularQuímica endocítica y medicinalLa endocitosismoléculas polares y grandesMedicina de precisiónmoléculas inducidas por la proximidad

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