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Updated: May 17, 2025

Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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Aprovechar la deubiquitinasa USP1 para la estabilización de proteínas dirigida

Chao Qian1, Zhen Wang2, Yan Xiong1

  • 1Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

Journal of the American Chemical Society
|April 19, 2025
PubMed
Resumen

Los investigadores desarrollaron una nueva tecnología de quimera dirigida a la deubiquitinasa (DUBTAC) utilizando USP1 para estabilizar las proteínas, lo que es prometedor para el tratamiento del cáncer. Esto amplía el arsenal de DUBTAC para la estabilización de proteínas dirigidas.

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