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Videos de Conceptos Relacionados

iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.0K
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
1.6K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Video Experimental Relacionado

Updated: May 9, 2025

Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts
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Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts

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Las células madre como modelos para la reprogramación y la reparación

Magdalena Götz1,2,3, Maria-Elena Torres-Padilla4,5

  • 1Institute of Stem Cell Research, Helmholtz Center Munich, Munich, Germany.

Science (New York, N.Y.)
|May 1, 2025
PubMed
Resumen

Las células madre ofrecen terapias celulares prometedoras al diferenciarse en varios tipos de células. Comprender la biología y la reprogramación de las células madre es clave para reparar los tejidos y desarrollar futuros tratamientos de medicina regenerativa.

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Last Updated: May 9, 2025

Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts
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Área de la Ciencia:

  • Biología de las células madre
  • Medicina regenerativa
  • La reprogramación celular

Sus antecedentes:

  • Las células madre son una fuente vital para terapias celulares.
  • Su potencial de diferenciación es crucial para la reparación de los tejidos y la tolerancia inmune.
  • Décadas de investigación se centran en el aprovechamiento de las capacidades de las células madre.

Objetivo del estudio:

  • Revisar los principios fundamentales de la biología de las células madre de los mamíferos.
  • Para explorar las técnicas de reprogramación celular.
  • Para discutir las aplicaciones terapéuticas de las células madre y la reprogramación.

Principales métodos:

  • Revisión de la literatura existente sobre la biología de las células madre.
  • Análisis de las estrategias de reprogramación directa, incluidas las células madre pluripotentes inducidas.
  • Examen de las aplicaciones terapéuticas para la reparación de tejidos y la modulación inmune.

Principales resultados:

  • La diferenciación de células madre es clave para las estrategias terapéuticas.
  • La reprogramación permite la generación de tipos específicos de células para la terapia.
  • Comprender la función de las células madre es crucial para la medicina regenerativa.

Conclusiones:

  • La biología de las células madre y la reprogramación son fundamentales para el avance de las terapias celulares.
  • El potencial terapéutico futuro radica en el aprovechamiento de la diferenciación y reprogramación de las células madre.
  • Esta revisión proporciona información sobre los tratamientos actuales y futuros basados en células madre.