Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Abnormal Proliferation02:23

Abnormal Proliferation

4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

11.8K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
11.8K
Skin Cancer01:30

Skin Cancer

4.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.0K
Tumor Progression02:07

Tumor Progression

6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Bringing cognitive behavioral therapy for nightmares to patients with trauma: increasing access and feasibility via primary and acute care.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2026
Same author

Countermovement Jump Responses During an Academy Rugby League In-Season.

Journal of strength and conditioning research·2026
Same author

Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn's disease pathogenesis.

Nature genetics·2026
Same author

Observational study of predictors and outcomes of lung cancer in never-smokers in the UK (OLIVE): study protocol.

BMJ open respiratory research·2026
Same author

Interventions for Obstructive Eustachian Tube Dysfunction: An Evidence-Based Umbrella Review of Efficacy and Safety.

Otolaryngologic clinics of North America·2026
Same author

Subclonal immune evasion in non-small cell lung cancer.

Cancer cell·2026

Video Experimental Relacionado

Updated: Jun 15, 2025

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
07:53

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Published on: March 17, 2020

7.1K

Dinámica clonal de las células basales aberrantes forma carcinogénesis pulmonar temprana

Sandra Gómez-López1, Ahmed S N Alhendi1, Moritz J Przybilla2

  • 1Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.

Science (New York, N.Y.)
|May 1, 2025
PubMed
Resumen

La exposición a carcinógenos impulsa los precursores del carcinoma de células escamosas del pulmón (LUSC) a través del crecimiento y la expansión de las células basales competitivas. Estos hallazgos revelan cómo el cáncer de pulmón en etapa temprana se desarrolla a partir de clones mutados a través del árbol bronquial.

Más Videos Relacionados

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

12.4K
Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea
11:52

Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea

Published on: September 14, 2012

14.3K

Videos de Experimentos Relacionados

Last Updated: Jun 15, 2025

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
07:53

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Published on: March 17, 2020

7.1K
Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

12.4K
Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea
11:52

Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea

Published on: September 14, 2012

14.3K

Área de la Ciencia:

  • Medicina de los pulmones
  • Biología del cáncer
  • Dinámica Celular

Sus antecedentes:

  • Las lesiones escamosas preinvasivas del pulmón preceden al carcinoma de células escamosas del pulmón (LUSC).
  • Los mecanismos celulares que impulsan la formación de estas lesiones precursoras siguen siendo en gran medida desconocidos.
  • Comprender estos eventos tempranos es crucial para desarrollar estrategias efectivas de prevención y detección temprana del cáncer de pulmón.

Objetivo del estudio:

  • Investigar los eventos celulares y la dinámica clonal que subyacen a la formación de lesiones pulmonares escamosas preinvasivas.
  • Identificar los procesos celulares clave que conducen al desarrollo del carcinoma de células escamosas del pulmón (LUSC).
  • Explorar el concepto de cancerización de campo en el contexto de las lesiones escamosas pulmonares.

Principales métodos:

  • Se utilizó un modelo de ratón inducido por carcinógenos para el desarrollo del carcinoma de células escamosas pulmonares (LUSC).
  • Analizó la competencia de células basales, la expansión clonal y la movilización a lo largo de las vías respiratorias.
  • Se llevó a cabo la secuenciación en múltiples sitios en pacientes humanos para confirmar los hallazgos en distintas regiones de las vías respiratorias.

Principales resultados:

  • La exposición a carcinógenos indujo una competencia no neutral entre las células basales, lo que condujo a expansiones clonales aberrantes.
  • Las células basales se movilizaron a lo largo de las vías respiratorias, contribuyendo a la formación de lesiones.
  • Las lesiones preinvasivas se originaron de unos pocos clones dominantes y altamente mutados que afectaron grandes áreas del árbol bronquial.
  • Los datos de pacientes humanos confirmaron lesiones preinvasivas relacionadas clonalmente en diferentes ubicaciones de las vías respiratorias.

Conclusiones:

  • Se produce una transición significativa en la dinámica clonal de las células basales y el destino celular durante el desarrollo de la lesión preinvasiva.
  • Estos cambios celulares son los principales impulsores de la cancerización de campo en el pulmón.
  • El estudio proporciona información crítica sobre la patogénesis temprana del carcinoma de células escamosas del pulmón (LUSC).