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Áreas de investigación Ciencias Biomédicas y Clínicas Bioquímica médica y metabolómica Medicina metabólica
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Ciencias Biomédicas y Clínicas
Bioquímica médica y metabolómica
Medicina metabólica
Producción y consumo de metabolitos entre órganos en condiciones saludables y aterogénicas

Producción y consumo de metabolitos entre órganos en condiciones saludables y aterogénicas

Hosung Bae ¹, Sunhee Jung ¹, Johnny Le ¹, Ian Tamburini ¹, Joohwan Kim ², Eric Wang ³, Won-Suk Song ¹, Wonsuk Choi ¹, Ki-Hong Jang ², Taekyung Kang ¹, Miranda L Lopez ⁴, Cuauhtemoc Ramirez ⁵, Ipsita Mohanty ⁶, Miranda E Kelly ¹, Jessie Kim ¹, Raymond Kim ¹, Sang Hee Park ¹, Jongwon Baek ¹, Bryan Mendez ¹, Paul Petrus ⁷, Thomas Q de Aguiar Vallim ⁸, Dequina A Nicholas ⁹, Quinton Smith ¹⁰, Gina Lee ¹¹, Marcus Seldin ¹², Cholsoon Jang ¹³

Hosung Bae ¹, Sunhee Jung ¹, Johnny Le ¹

¹Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
²Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.
³Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.
⁴Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
⁵Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.
⁶Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
⁷Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Department of Medicine (H7), Karolinska Institutet, Stockholm, Sweden.
⁸Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
⁹Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA; Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA, USA.
¹⁰Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA; Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, USA.
¹¹Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA; Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA.
¹²Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA, USA.
¹³Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA.

⁰Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.

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28 de mayo de 2025

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28 de mayo de 2025

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Ver abstracta en PubMed

Resumen

Este resumen es generado por máquina.

Este estudio traza cómo los órganos producen y consumen metabolitos, revelando cómo la dieta y la enfermedad alteran este equilibrio. Los hallazgos clave muestran que la liberación de ácido biliar extrahepático contribuye a la inflamación vascular y la aterosclerosis.

Área De La Ciencia

Investigación metabólica
Investigación en enfermedades cardiovasculares
Ciencias de la nutrición

Sus Antecedentes

Los órganos de los mamíferos producen y consumen constantemente metabolitos, esenciales para la salud.
El alcance completo del intercambio de metabolitos de órganos y su alteración por dieta/enfermedad sigue sin estar claro.

Objetivo Del Estudio

Crear un atlas completo de la producción y el consumo de metabolitos de órganos.
Para investigar cómo el ayuno / alimentación, la dieta occidental y las enfermedades cardiovasculares afectan este panorama metabólico.

Principales Métodos

Utilizó metabolomía arteriovenosa, transcriptómica tisular y conjuntos hormonales en cerdos.
Examinó múltiples afecciones fisiopatológicas, incluida la dieta occidental y la deficiencia del receptor de lipoproteínas de baja densidad (LDLR).

Principales Resultados

Descubrió numerosas vías de producción/consumo de metabolitos dependientes y independientes de la alimentación en los órganos.
Interrupciones identificadas por la dieta occidental a través de gradientes metabólicos y hormonas alterados.
Se observó la liberación de ácido biliar extrahepático tanto en la dieta occidental como en la deficiencia de LDLR, relacionada con la inflamación vascular y la aterosclerosis.

Conclusiones

Reveló una intrincada interconexión metabólica entre órganos en varios estados fisiopatológicos.
Proporcionó información bioquímica sobre el impacto de la dieta y las enfermedades cardiometabólicas en el metabolismo.

Palabras clave:

Metabolomía arteriovenosa metabolismo de los ácidos biliares Enfermedad cardiovascular el metabolito circulante flujo Intercambio entre órganos Trazado por isótopos receptor de lipoproteínas de baja densidad Metabolomía La dieta occidental

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