Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Gene Duplication and Divergence02:37

Gene Duplication and Divergence

6.3K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
6.3K
Human Genetics01:28

Human Genetics

730
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
730
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

2.6K
2.6K
Synteny and Evolution02:31

Synteny and Evolution

3.4K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.4K
Biological Influences on Intelligence01:30

Biological Influences on Intelligence

220
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
220
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

4.3K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
4.3K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Influence of <i>cis</i>-regulatory elements on expression divergence in human segmental duplications.

Genome research·2026
Same author

The unconventional kinesin Kif26a is required for the guidance of major axon tracts in the developing mouse brain.

bioRxiv : the preprint server for biology·2026
Same author

Sex-Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis.

Annals of clinical and translational neurology·2026
Same author

Cortex-Wide Neuron Activation after Traumatic Brain Injury in Mice.

eNeuro·2026
Same author

Roles of sonic hedgehog signaling in retinal patterning and neurogenesis during mammalian eye development.

Development (Cambridge, England)·2026
Same author

Uncoupling neocortical neuron fate and migration via a Let-7-RBX2 axis.

Proceedings of the National Academy of Sciences of the United States of America·2026

Video Experimental Relacionado

Updated: Sep 14, 2025

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
07:13

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function

Published on: November 29, 2024

1.3K

Las expansiones genéticas específicas del ser humano contribuyen a la evolución del cerebro

Daniela C Soto1, José M Uribe-Salazar1, Gulhan Kaya1

  • 1Department of Biochemistry & Molecular Medicine, MIND Institute, University of California, Davis, Davis, CA 95616, USA; Genome Center, University of California, Davis, Davis, CA 95616, USA.

Cell
|July 22, 2025
PubMed
Resumen

Las duplicaciones genéticas específicas del ser humano son clave para la evolución del cerebro. Los investigadores identificaron 362 parólogos en todos los humanos, con dos genes, GPR89B y FRMPD2B, que muestran roles potenciales en el desarrollo y las características del cerebro humano.

Palabras clave:
el cerebroVariación del número de ejemplaresduplicaciones genéticasexpresión génicaLa evolución del hombreSelección naturaldesarrollo neurológicoduplicaciones segmentalessecuenciaciónPescado cebra

Más Videos Relacionados

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain
09:59

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain

Published on: March 31, 2022

2.8K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.7K

Videos de Experimentos Relacionados

Last Updated: Sep 14, 2025

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
07:13

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function

Published on: November 29, 2024

1.3K
AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain
09:59

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain

Published on: March 31, 2022

2.8K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.7K

Área de la Ciencia:

  • La genómica
  • Biología evolutiva
  • La neurociencia

Sus antecedentes:

  • Se supone que los eventos de duplicación de genes en el linaje humano impulsan la evolución del cerebro.
  • La identificación de estos genes duplicados es un reto debido a los errores de ensamblaje del genoma.

Objetivo del estudio:

  • Identificar las familias de genes y parálogos específicos del ser humano que contribuyen a las características universales del cerebro humano.
  • Investigar el papel funcional de estos genes en el desarrollo del cerebro.

Principales métodos:

  • Utilizó una secuencia completa del genoma telómero a telómero para el descubrimiento de genes.
  • Empleó secuenciación de ADN de larga lectura para detectar firmas de selección en genomas humanos modernos.
  • Generó modelos de nocaut CRISPR de pez cebra y realizó experimentos de humanización de ARNm.

Principales resultados:

  • Identificó 213 familias de genes específicos humanos, con 362 parálogos presentes en todos los genomas humanos modernos y transcriptomas cerebrales probados.
  • Se han detectado señales de selección en parálogos específicos, incluido el CD8B.
  • GPR89B implicado en la expansión cerebral dependiente de la dosis y FRMPD2B en la señalización alterada de la sinapsis en modelos de pez cebra.

Conclusiones:

  • El estudio proporciona un recurso integral para comprender la expansión génica en la evolución del cerebro humano.
  • GPR89B y FRMPD2B se destacan como contribuyentes potenciales a las características distintas del cerebro humano.