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Los aglutinantes de pMHC diseñados de nuevo facilitan la citotoxicidad mediada por las células T hacia las células

Kristoffer Haurum Johansen1, Darian Stephan Wolff2, Beatrice Scapolo1,2

  • 1Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.

Science (New York, N.Y.)
|July 24, 2025
PubMed
Resumen

Los investigadores desarrollaron una nueva plataforma utilizando modelos generativos para diseñar minivínculos que se dirigen a los receptores de células T específicos del cáncer (TCR). Este enfoque diseñó con éxito un aglutinante de alta afinidad, lo que condujo a la muerte de las células de melanoma y mostró una promesa para la inmunoterapia de precisión.

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