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Cheng Cheng^1,2, Yan Zheng¹, Xin Wang¹

¹College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, China.

BMC veterinary research

|August 20, 2025

Resumen

Un nuevo probiótico derivado de la cabra, Lactobacillus amylovorus, restauró efectivamente la salud intestinal en cabras con síndrome de riñón flojo (FKS). Esta prometedora intervención mejoró la diversidad de la microbiota intestinal y redujo las bacterias dañinas, ofreciendo un nuevo tratamiento para FKS.

Área de la Ciencia:

Microbiología veterinaria
Probióticos de origen animal
Salud de las cabras

Sus antecedentes:

El síndrome del riñón flojo (FKS) causa una mortalidad significativa en la cría de cabras debido a problemas metabólicos y disbiosis intestinal.
El desarrollo de intervenciones eficaces es crucial para reducir las pérdidas relacionadas con el FKS.

Objetivo del estudio:

Para aislar un probiótico derivado de la cabra.
Evaluar su eficacia en el restablecimiento de la homeostasis intestinal en cabras afectadas por FKS.

Principales métodos:

Aislamiento y confirmación de Lactobacillus amylovorus mediante secuenciación del ARNr 16S.
Evaluación de la tolerancia de los probióticos al pH bajo, a las sales biliares y al calor.
Evaluación de la actividad antimicrobiana contra patógenos como E. coli y S. aureus.
Análisis de los cambios de la microbiota intestinal en cabras afectadas por FKS después de la administración de probióticos.

Principales resultados:

El aislado de L. amylovorus demostró una tolerancia significativa a las condiciones ácidas, a las sales biliares y al calor.
Mostró efectos inhibidores contra los patógenos comunes de las cabras, Escherichia coli y Staphylococcus aureus.
El tratamiento con probióticos en cabras afectadas por FKS condujo a un aumento significativo de la diversidad microbiana intestinal (índices de Shannon y Simpson).
La abundancia relativa de los géneros beneficiosos (Lactobacillus, Ruminococcus) aumentó, mientras que la EscherichiaShigella patógena disminuyó.

Conclusiones:

La L. amylovorus derivada de la cabra posee características probióticas robustas, incluida la inhibición del patógeno y la tolerancia a las condiciones adversas.
Este probiótico moduló efectivamente la microbiota intestinal en cabras afectadas por FKS, restaurando la homeostasis.
L. amylovorus muestra un potencial significativo como un nuevo agente terapéutico para prevenir y tratar el síndrome del riñón flojo.

Palabras clave:

Lactobacillus Amylovorus y sus derivados Aplicaciones clínicas Síndrome del niño flojo Características de crecimiento Probiótico

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