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La exposición a los ftalatos está asociada con la aterosclerosis coronaria subclínica: el estudio de salud de los
Diana María Mérida1,2,3, Carolina Torrijo-Belanche4, Belén Moreno-Franco4,5,6
1Department of Preventive Medicine and Public Health. School of Medicine, Universidad Autónoma de Madrid, 28029 Madrid, Spain.
American journal of preventive cardiology
|August 20, 2025
Resumen
La exposición al monoetil ftalato (MEP) está relacionada con una mayor prevalencia de aterosclerosis coronaria subclínica (ACS) en los trabajadores masculinos. La reducción de la exposición al MEP puede ayudar a prevenir la enfermedad cardiovascular en etapa temprana.
Área de la Ciencia:
- Salud del medio ambiente
- Investigación cardiovascular
- Toxicología
Sus antecedentes:
- Los ftalatos están relacionados con los mecanismos de las enfermedades cardiovasculares, incluido el estrés oxidativo y la disfunción endotelial.
- La aterosclerosis coronaria subclínica (ACS) es un indicador temprano de enfermedad cardiovascular.
- La evaluación del papel de la exposición a los ftalatos en el ACV es crucial para la salud pública.
Objetivo del estudio:
- Evaluar la asociación entre la exposición a los ftalatos y la aterosclerosis coronaria subclínica (ACS).
- Investigar metabolitos específicos de ftalatos y su correlación con la prevalencia de ACS.
Principales métodos:
- Se analizaron 1119 trabajadores masculinos de una planta de ensamblaje de automóviles para detectar metabolitos de ftalatos en la orina.
- La aterosclerosis coronaria subclínica (ACS) fue definida por las puntuaciones de calcio en las arterias coronarias.
- Se utilizaron modelos de regresión logística ajustados por factores de confusión para determinar las asociaciones.
Principales resultados:
- La prevalencia de SCA fue del 10,2% entre los participantes.
- Se encontraron concentraciones más altas de ftalato de monoetil (MEP) en individuos con SCA.
- El aumento de la exposición al MEP se asoció significativamente con una mayor prevalencia de SCA (OR: 1,21).
Conclusiones:
- La exposición al monoetil ftalato (MEP) está asociada con un aumento de la prevalencia de la aterosclerosis coronaria subclínica (ACS).
- Estos hallazgos sugieren que el MEP puede contribuir al desarrollo temprano de enfermedades cardiovasculares.
- La reducción de la exposición a los ftalatos podría ser una estrategia para la prevención primaria de enfermedades cardiovasculares.
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