Video Experimental Relacionado
Updated: Sep 8, 2025
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
16.4K
Nuevos biomarcadores de la inflamación asociados con la hemodiálisis
Fátima Guerrero1, Andrés Carmona1, Maria Jose Jiménez1
1Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba, Reina Sofía University Hospital, Córdoba, Spain.
Clinical kidney journal
|August 20, 2025
Resumen
La hemodiálisis (HD) aumenta la inflamación y el estrés oxidativo, indicado por el aumento de los monocitos activados y los marcadores inflamatorios durante el primer año. Esta inflamación subclínica puede explicar el daño cardiovascular en pacientes sometidos a EH.
Área de la Ciencia:
- Nefrología
- Inmunología
- La bioquímica
Sus antecedentes:
- El primer año de hemodiálisis está relacionado con una alta mortalidad, a menudo debido al aumento de la inflamación.
- Los marcadores inflamatorios tradicionales muestran cambios mínimos, lo que sugiere que hay otros factores involucrados.
- Este estudio investiga el impacto de la EH en la microinflamación y el estrés oxidativo en pacientes urémicos.
Objetivo del estudio:
- Evaluar el efecto de la hemodiálisis sobre la microinflamación y el estrés oxidativo.
- Identificar nuevos marcadores inflamatorios asociados con el tratamiento temprano de la EH.
Principales métodos:
- Estudio longitudinal prospectivo de observación en 30 pacientes con EH.
- Análisis de muestras de sangre al inicio, 6 y 12 meses.
- Cuantificación de monocitos proinflamatorios, análisis proteómico, sulfato de indoxilo (IS), GDF-15, estado oxidativo y expresión de miARN.
Principales resultados:
- Una nueva población de monocitos activados aumentó durante 1 año de EH.
- Las concentraciones séricas de 29 proteínas relacionadas con la inflamación aumentaron, mientras que los receptores del factor inhibidor de la leucemia disminuyeron.
- Correlación positiva entre IS y GDF-15; disminución de la expresión de miRNAs específicos (por ejemplo, miRNA-126-3p, -146a-5p).
Conclusiones:
- La EH tiene un impacto significativo en la inflamación y el estrés oxidativo, evidenciado por un aumento de monocitos activados y marcadores inflamatorios.
- La inflamación subclínica observada puede contribuir al daño cardiovascular en pacientes con EH.
- Los hallazgos mejoran la comprensión de las complicaciones relacionadas con la EH.
Videos de Conceptos Relacionados
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
213
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
213
01:24Hemodialysis II: Procedure and Complications
126
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
126
01:25Hemodialysis III: Nursing Management
172
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
172
01:24Chronic Kidney Disease II: Clinical Manifestations
81
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
81
01:24Serum Studies: Renal Function Tests
42
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
42
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
57
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
57