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Aumento de la aparición de aura de migraña y susceptibilidad a la propagación de despolarizaciones en altitud
Katelyn M Reinhart1, Melissa M Cortez1, Cecilia Martindale1,2
1Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT.
medRxiv : the preprint server for health sciences
|August 20, 2025
Resumen
El ascenso a gran altitud puede desencadenar dolores de cabeza, y las apariciones de aura de migraña aumentan con la elevación. Este estudio en humanos y ratones sugiere un mecanismo potencial para los síntomas neurológicos relacionados con la altitud.
Área de la Ciencia:
- Neurología
- Medicina de altitud
- La neurociencia
Sus antecedentes:
- El dolor de cabeza, incluido el mal de montaña agudo, es común en las altitudes altas y comparte características con la migraña.
- La prevalencia de la migraña puede ser elevada en elevaciones moderadas y altas.
- El aura de la migraña es un síntoma neurológico que puede desencadenarse por varios factores.
Objetivo del estudio:
- Investigar la relación entre la elevación y la aparición de aura de migraña.
- Explorar los posibles mecanismos subyacentes de los síntomas neurológicos relacionados con la altitud.
- Informar las estrategias de mitigación para las personas que viven en altitudes más altas.
Principales métodos:
- Pruebas clínicas que incluyen revisión de gráficos, comparación prospectiva de cohortes y análisis de registros multicéntricos de dolor de cabeza y registros médicos electrónicos.
- Datos experimentales de ratones alojados en cámaras de altitud para evaluar la susceptibilidad a la difusión de la despolarización (DS).
Principales resultados:
- Se identificó una mayor incidencia de aura de migraña con aumento de la elevación en múltiples conjuntos de datos clínicos.
- La susceptibilidad a la despolarización de propagación (SD) en ratones aumentó con la altitud simulada.
- Los hallazgos sugieren un vínculo entre la elevación, el aura de la migraña y la SD.
Conclusiones:
- La elevación está asociada con una mayor incidencia de aura de migraña.
- El aumento de la susceptibilidad a la SD en altitudes simuladas proporciona un mecanismo potencial para el aura relacionada con la altitud.
- Estos hallazgos pueden ayudar a desarrollar estrategias específicas para los casi mil millones de personas que viven en altitudes más altas en todo el mundo.
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