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La perturbación de la calreticulina potencia la inmunidad antitumoral mediada por las células T CD8+

Kaiyang Tang1, Lijian Wu1, Yuanzhi Hu1

  • 1School of Basic Medical Sciences, State Key Laboratory of Molecular Oncology, Tsinghua University , Beijing, China.

The Journal of experimental medicine
|August 20, 2025
PubMed
Resumen

La inactivación de los componentes de la calreticulina (CALR) y del complejo de carga de péptidos (PLC) aumenta inesperadamente las respuestas de las células T CD8+ contra los tumores. Este descubrimiento ofrece una nueva estrategia para mejorar la eficacia de la inmunoterapia contra el cáncer.

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