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Conservación evolutiva y implicaciones en el cáncer de la vía de señalización WNT

Devesh Prajapati¹, Gayatri Ambere¹, Dyandevi Mathure¹

¹Department of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, Pune, India.

Medical oncology (Northwood, London, England)

|August 20, 2025

Resumen

La vía de señalización WNT es crucial en el desarrollo y la progresión del cáncer. Los compuestos bioactivos como la curcumina y el resveratrol son prometedores en el bloqueo de la señalización WNT para el tratamiento del cáncer colorrectal.

Área de la Ciencia:

Biología molecular
Biología del cáncer
Farmacología

Sus antecedentes:

La vía de señalización WNT regula los procesos celulares fundamentales como la apoptosis, la proliferación y el metabolismo.
La desregulación de la señalización WNT está implicada en varios tipos de cáncer, incluido el cáncer colorrectal (CRC).
Comprender los componentes de la vía WNT es vital para desarrollar terapias dirigidas al cáncer.

Objetivo del estudio:

Revisar los mecanismos moleculares de la vía de señalización WNT en el desarrollo y el cáncer.
Explorar el potencial terapéutico de la señalización WNT en el cáncer colorrectal.
Resaltar los compuestos bioactivos y los inhibidores que modulan la vía WNT para el tratamiento del CCR.

Principales métodos:

Revisión exhaustiva de la literatura sobre los mecanismos de señalización de WNT, sus componentes y objetivos terapéuticos.
Análisis de los compuestos bioactivos (flavonoides, curcumina, resveratrol) y sus efectos inhibidores de la WNT.
Examen de ensayos clínicos de inhibidores de la vía WNT en el tratamiento del cáncer.

Principales resultados:

Los componentes de la vía WNT juegan un papel importante en el estímulo del cáncer, la metástasis y la vigilancia inmune.
Los compuestos bioactivos, en particular los flavonoides, demuestran potencial para inhibir la señalización WNT.
Se está investigando la eficacia clínica de varios inhibidores dirigidos a PORCN, FZD y β-catenina.

Conclusiones:

La orientación de la vía de señalización WNT ofrece oportunidades terapéuticas prometedoras para el cáncer colorrectal.
Los compuestos bioactivos y los nuevos inhibidores representan un avance significativo en la terapia de CRC dirigida a WNT.
La investigación adicional sobre la modulación de la vía WNT es crucial para mejorar los resultados del tratamiento del cáncer.

Palabras clave:

Proceso bioquímico Desarrollo del cáncer Con el pelo fruncido Objetivos terapéuticos No lo sé.

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