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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Acute Kidney Injury I: Introduction01:22

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Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Acute Kidney Injury III: Clinical Manifestations01:29

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Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
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Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
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  3. Asociación Entre La Función Renal Y La Incidencia De Resultados Cardiovasculares Adversos Importantes 1 Año Después Del Primer Infarto Agudo De Miocardio
  1. Home
  3. Asociación Entre La Función Renal Y La Incidencia De Resultados Cardiovasculares Adversos Importantes 1 Año Después Del Primer Infarto Agudo De Miocardio

Video Experimental Relacionado

Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Asociación entre la función renal y la incidencia de resultados cardiovasculares adversos importantes 1 año después

Daniel Medeiros Moreira1,2, Marco Antônio de Sousa1, Maria Fernanda Scarduelli Cechinel1

  • 1Universidade do Sul de Santa Catarina, Palhoça, SC - Brasil.

Arquivos brasileiros de cardiologia
|August 20, 2025

Ver abstracta en PubMed

Resumen
Este resumen es generado por máquina.

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Un mayor aclaramiento de la creatinina en pacientes con infarto agudo de miocardio (AMI) está relacionado con un menor número de eventos cardiovasculares y una menor mortalidad dentro de un año. Esto pone de relieve la importancia de la evaluación de la función renal después de la AMI.

Área de la Ciencia:

  • Cardiología
  • Nefrología
  • Investigación clínica

Sus antecedentes:

  • Las enfermedades cardiovasculares (ECV) son una de las principales causas de mortalidad en el mundo.
  • La disfunción renal es una comorbilidad común en pacientes con ECV.
  • Comprender la interacción entre la función renal y los resultados cardíacos es crucial.

Objetivo del estudio:

  • Investigar la asociación entre el aclaramiento de la creatinina y los resultados cardiovasculares a 1 año en pacientes con infarto agudo de miocardio (AMI).
  • Determinar si la función renal afecta el riesgo de acontecimientos adversos cardiovasculares importantes (MACE) y la mortalidad después de un IAM.

Principales métodos:

  • Estudio prospectivo de cohorte de 1.324 pacientes hospitalizados por su primer infarto miocárdico agudo.
  • Se midió y analizó el aclaramiento de la creatinina.
  • Los resultados cardiovasculares incluyeron IAM recurrente, accidente cerebrovascular y muerte cardiovascular.

    • Principales resultados:

    • La disminución del aclaramiento de la creatinina (< 60 ml/ min) se asoció con hipertensión, diabetes y dislipidemia.
    • Un mayor aclaramiento de la creatinina se correlacionó con un riesgo reducido de MACE dentro de 1 año (HR: 0,992; p=0,030).
    • El aumento del aclaramiento de la creatinina también se relacionó con una mortalidad global significativamente menor (HR: 0,984; p=0,021).

    Conclusiones:

    • Un mayor aclaramiento de la creatinina es un factor protector contra el MACE y la mortalidad en el año siguiente al IMA.
    • La función renal, según lo indicado por el aclaramiento de la creatinina, es un marcador pronóstico importante en pacientes con IAM.