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PANoptosis en enfermedades infecciosas: Mecanismos, potencial terapéutico y direcciones futuras
Ruifeng Zhang1, Zhonghe Wang1, Yang Shao1
1School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Biochemical and biophysical research communications
|August 20, 2025
Resumen
La panoptosis, una forma programada de muerte celular, integra la piroptosis, la apoptosis y la necroptosis para combatir las infecciones y mantener el equilibrio inmunológico. Esta revisión explora los mecanismos de PANoptosis y el potencial terapéutico para las enfermedades, centrándose en el complejo PANoptosome.
Área de la Ciencia:
- Inmunología
- Biología celular
- Biología molecular
Sus antecedentes:
- La panoptosis es una vía de muerte celular programada integrada que incluye piroptosis, apoptosis y necroptosis.
- El complejo PANoptosome es central para orquestar estas respuestas de muerte celular.
- La PANoptosis desregulada contribuye al daño tisular y al desequilibrio inmunológico durante las infecciones.
Objetivo del estudio:
- Revisar los hallazgos recientes sobre los mecanismos de la PANoptosis.
- Evaluar el potencial terapéutico de la PANoptosis en enfermedades relacionadas con infecciones.
- Identificar las direcciones de investigación futuras para comprender y modular la PANoptosis.
Principales métodos:
- Revisión de la literatura de las investigaciones actuales sobre la panoptosis.
- Análisis del papel de la panoptosis en diversas enfermedades infecciosas.
- Evaluación de las estrategias terapéuticas dirigidas a los mediadores de la PANoptosis.
Principales resultados:
- La panoptosis juega un papel crítico en la defensa del huésped contra infecciones virales, bacterianas, fúngicas y parasitarias.
- La activación excesiva de la PANóptosis puede conducir a un daño inflamatorio perjudicial y a una desregulación inmune.
- Los mediadores clave como ZBP1, RIPK3 y Caspase-8 son cruciales para la PANoptosis.
Conclusiones:
- La panoptosis es un mecanismo vital para la homeostasis inmune y el control de la infección.
- La orientación de la PANoptosis ofrece un potencial terapéutico para el manejo de enfermedades infecciosas.
- Se necesita más investigación para dilucidar la dinámica del PANoptosoma y desarrollar terapias dirigidas.
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