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Disbiosis intestinal, inflamación de bajo grado y gravedad de la insuficiencia renal en ancianos con nefropatía
Yan-Ping Shi1, Zhang-Lei Pan1, Jing Zhang1
1Department of Nephrology, The Second Affiliated Hospital of Shandong First Medical University, Tai'an 271000, Shandong Province, China.
World journal of diabetes
|August 21, 2025
Resumen
La nefropatía diabética (DN) en adultos mayores está relacionada con el desequilibrio de las bacterias intestinales. La reducción de las bacterias beneficiosas y el aumento de las bacterias dañinas se correlacionan con la aparición y la progresión de DN, lo que afecta la función renal.
Área de la Ciencia:
- Microbiología
- Nefrología
- Enfermedad de los ancianos
Sus antecedentes:
- Los mecanismos de la nefropatía diabética (DN) aún no están claros.
- El desequilibrio de la microbiota intestinal y la inflamación están cada vez más implicados en el desarrollo de la DN.
- Se necesita más investigación para aclarar estas complejas relaciones.
Objetivo del estudio:
- Investigar el vínculo entre la disbiosis de la microbiota intestinal, la inflamación y la función renal en pacientes mayores con DN.
- Correlacione estos factores con la gravedad de la DN.
- Proporcionar una base para las estrategias de prevención y tratamiento de la EN.
Principales métodos:
- Comparación de la microbiota intestinal, los marcadores inflamatorios y la función renal en 167 pacientes mayores con DN y 85 controles.
- Se realizó un seguimiento de un año para observar la progresión de la enfermedad.
- Se analizó la composición de la microbiota y los cambios en los marcadores inflamatorios a través de las etapas del ADN.
Principales resultados:
- Los pacientes con DN mostraron una menor diversidad microbiana (índices Chao, Ace, Shannon) y una mayor abundancia de bacterias dañinas (por ejemplo, Klebsiella, Enterococcus).
- Reducción de la diversidad microbiana y cambios bacterianos específicos correlacionados con deterioro de la función renal (tasa de filtración glomerular).
- La disbiosis intestinal predijo un mayor riesgo de DN y una disminución más rápida de la función renal durante un año.
Conclusiones:
- El inicio y la progresión de la nefropatía diabética en adultos mayores están fuertemente asociados con la composición de la microbiota intestinal.
- La disbiosis intestinal grave, caracterizada por bajas bacterias beneficiosas y altas bacterias dañinas, aumenta el riesgo y la progresión de DN.
- Dirigirse a la microbiota intestinal puede ofrecer un potencial terapéutico para la DN.
Palabras clave:
Nefropatía diabéticaMetabolismo de la glucosaDesequilibrio de la flora intestinalEl metabolismo de los lípidosEstado microinflamatorioDeterioro de la función renalMás Videos Relacionados
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